Clemente Capasso

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Name: Clemente Capasso

Date and Place of Birth: 22.07.1965, Napoli, Italy

Address: Institute of Biosciences and Bioresources, National Research Council, - Via Pietro Castellino 111- 80131, Napoli, Italy,

Tel: ++39 0816132558,

E-mail: clemente.capasso@ibbr.cnr.it

Education and Training

(From 1992-present)

1992 Achieved the master degree in Biology cum laude at University of Naples “Federico II”.

1993-1994 Post-Laurea training: University Federico II of Naples, Department of Evolutionary and Comparative Biology. Mentor: Prof. Elio Parisi.-Works on metallothioneins (MTs) in marine and terrestrial organisms

1993-1994 Awarded a C.N.R. fellowship: CNR. Institute of Protein Biochemistry and Enzymology of Naples. Mentor: Prof. Elio Parisi. Continues work on MTs.

1/10/1994-1/12/1994 Visiting Scientist: Biological Station of Roscoff (France, CNR/CNRS cooperation). Works on metal-binding proteins in bacteria.

1995-1996 Awarded a CNR fellowship: University of Genova, Italy. Works on protein crystallization (serine proteinases, superoxide dismutase, and hexokinase).

1/10/1996-31/12/2013 Researcher at CNR-Institute of Protein Biochemistry and Enzymology, Naples, Italy. Principal investigator of the scientific project: "Cloning, heterologous expression and structure of proteins and enzymes from Antarctic organisms". Works on multigene family proteins (metallothioneins, aspartic proteinases, and carbonic anhydrases).

12/05/1997-09/07/1997 Visiting Scientist: School of Molecular and Medical Biosciences, University College, Cardiff. Works on the expression of heterologous proteins (MTs and aspartic proteinases) in E. coli.

2003-2004 Research Associate: University of Southern California Keck School of Medicine, Los Angeles, CA. Works on human 5-lipoxygenase.

1/12/2014-present Researcher at CNR- Institute of Biosciences and Bioresources (IBBR). Principal investigator of the scientific projects: 1) Evolution, adaptation, and biodiversity of carbonic anhydrases from Antarctic organisms; 2) Capture of the CO₂ from flue gases by using enzymes from moderately thermophilic microorganisms.

Scientific Activities

Clemente Capasso obtained his MSc in biology cum laude at the University of Naples ‘Federico II’ (Italy). His research interest at the Italian National Research Council (CNR; Rome, Italy) from 1992 to date has been the study of the structure/function relationship of both native and recombinant proteins from terrestrial and marine organisms. In particular, he studied metallothioneins and aspartic proteinases in Echinoderms and Antarctic fish. This research activity has allowed him to acquire extensive knowledge of most protein purification procedures as well as kinetic, chemical-physical, and structural characterization of enzymes. He also has experience with molecular biology techniques, such as nucleic acid isolation, cloning, and expression of recombinant proteins and enzymes in Escherichia coli. Recently, his research activity has been focused on the investigation of enzymes involved in the hydration of CO₂ (carbonic anhydrases) in extremophilic microorganisms. The preliminary results of this study are helpful in developing new methodologies for the use of enzymatic systems in biotechnologies. All of these activities have led to more than 150 publications in peer-reviewed journals. He has a long and strong scientific background, developed over 15 years of experience acquired by intense training in Italian and international laboratories. He is the Associate Editor of Journal of Enzyme Inhibition and Medicinal Chemistry and is on the Editorial Board of the Expert Opinion on Therapeutic Patents, Current Enzyme Inhibition, and International Journal of Molecular Science.

Recent publications

Journal Articles

[1] M. Mori, C. Capasso, F. Carta, W.A. Donald, C.T. Supuran, A deadly spillover: SARS-CoV-2 outbreak, Expert Opin Ther Pat (2020) 1-5.

[2] G. Salbitani, S. Del Prete, F. Bolinesi, O. Mangoni, V. De Luca, V. Carginale, W.A. Donald, C.T. Supuran, S. Carfagna, C. Capasso, Use of an immobilised thermostable alpha-CA (SspCA) for enhancing the metabolic efficiency of the freshwater green microalga Chlorella sorokiniana, J Enzyme Inhib Med Chem 35(1) (2020) 913-920.

[3] O. Ozensoy Guler, C.T. Supuran, C. Capasso, Carbonic anhydrase IX as a novel candidate in liquid biopsy, J Enzyme Inhib Med Chem 35(1) (2020) 255-260.

[4] M. Logozzi, D. Mizzoni, C. Capasso, S. Del Prete, R. Di Raimo, M. Falchi, D.F. Angelini, A. Sciarra, M. Maggi, C.T. Supuran, S. Fais, Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH, J Enzyme Inhib Med Chem 35(1) (2020) 280-288.

[5] S. Del Prete, A. Nocentini, C.T. Supuran, C. Capasso, Bacterial iota-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii, J Enzyme Inhib Med Chem 35(1) (2020) 1060-1068.

[6] S. Del Prete, A. Angeli, C. Ghobril, J. Hitce, C. Clavaud, X. Marat, C.T. Supuran, C. Capasso, Sulfonamide Inhibition Profile of the beta-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions, Metabolites 10(1) (2020).

[7] A. Angeli, S.D. Prete, C. Ghobril, J. Hitce, C. Clavaud, X. Marrat, W.A. Donald, C. Capasso, C.T. Supuran, Activation studies of the beta-carbonic anhydrases from Malassezia restricta with amines and amino acids, J Enzyme Inhib Med Chem 35(1) (2020) 824-830.

[8] A. Angeli, M. Pinteala, S.S. Maier, B.C. Simionescu, A. Milaneschi, G. Abbas, S. Del Prete, C. Capasso, A. Capperucci, D. Tanini, F. Carta, C.T. Supuran, Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria, Int J Mol Sci 21(2) (2020).

[9] S.A. Alissa, H.A. Alghulikah, A.L. ZA, S.M. Osman, S. Del Prete, C. Capasso, A. Nocentini, C.T. Supuran, Inhibition survey with phenolic compounds against the delta- and eta-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum, J Enzyme Inhib Med Chem 35(1) (2020) 377-382.

[10] S.A. Alissa, H.A. Alghulikah, Z.A. Alothman, S.M. Osman, S. Del Prete, C. Capasso, A. Nocentini, C.T. Supuran, Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of beta-class carbonic anhydrases from bacteria, fungi, and protozoa, J Enzyme Inhib Med Chem 35(1) (2020) 59-64.

[11] M. Ronci, S. Del Prete, V. Puca, S. Carradori, V. Carginale, R. Muraro, G. Mincione, A. Aceto, F. Sisto, C.T. Supuran, R. Grande, C. Capasso, Identification and characterization of the alpha-CA in the outer membrane vesicles produced by Helicobacter pylori, J Enzyme Inhib Med Chem 34(1) (2019) 189-195.

[12] A. Rogato, S. Del Prete, A. Nocentini, V. Carginale, C.T. Supuran, C. Capasso, Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors, J Enzyme Inhib Med Chem 34(1) (2019) 510-518.

[13] S.D. Prete, A. Angeli, C. Ghobril, J. Hitce, C. Clavaud, X. Marat, C.T. Supuran, C. Capasso, Anion Inhibition Profile of the beta-Carbonic Anhydrase from the Opportunist Pathogenic Fungus Malassezia Restricta Involved in Dandruff and Seborrheic Dermatitis, Metabolites 9(7) (2019).

[14] A. Nocentini, S.M. Osman, S. Del Prete, C. Capasso, A.L. ZA, C.T. Supuran, Extending the gamma-class carbonic anhydrases inhibition profiles with phenolic compounds, Bioorg Chem 93 (2019) 103336.

[15] R. Merlo, S. Del Prete, A. Valenti, R. Mattossovich, V. Carginale, C.T. Supuran, C. Capasso, G. Perugino, An AGT-based protein-tag system for the labelling and surface immobilization of enzymes on E. coli outer membrane, J Enzyme Inhib Med Chem 34(1) (2019) 490-499.

[16] M. Logozzi, C. Capasso, R. Di Raimo, S. Del Prete, D. Mizzoni, M. Falchi, C.T. Supuran, S. Fais, Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity, J Enzyme Inhib Med Chem 34(1) (2019) 272-278.

[17] H. Kucukbay, N. Bugday, F.Z. Kucukbay, E. Berrino, G. Bartolucci, S. Del Prete, C. Capasso, C.T. Supuran, Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates, Bioorg Chem 83 (2019) 414-423.

[18] R. Gitto, L. De Luca, F. Mancuso, S. Del Prete, D. Vullo, C.T. Supuran, C. Capasso, Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives, J Enzyme Inhib Med Chem 34(1) (2019) 1186-1192.

[19] S. Distinto, R. Meleddu, F. Ortuso, F. Cottiglia, S. Deplano, L. Sequeira, C. Melis, B. Fois, A. Angeli, C. Capasso, R. Angius, S. Alcaro, C.T. Supuran, E. Maccioni, Exploring new structural features of the 4-[(3-methyl-4-aryl-2.3-dihydro-1.3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases, J Enzyme Inhib Med Chem 34(1) (2019) 1526-1533.

[20] S. Del Prete, D. Vullo, C. Ghobril, J. Hitce, C. Clavaud, X. Marat, C. Capasso, C.T. Supuran, Cloning, Purification, and Characterization of a beta-Carbonic Anhydrase from Malassezia restricta, an Opportunistic Pathogen Involved in Dandruff and Seborrheic Dermatitis, Int J Mol Sci 20(10) (2019).

[21] S. Del Prete, R. Merlo, A. Valenti, R. Mattossovich, M. Rossi, V. Carginale, C.T. Supuran, G. Perugino, C. Capasso, Thermostability enhancement of the alpha-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASL(tag)), J Enzyme Inhib Med Chem 34(1) (2019) 946-954.

[22] S. Del Prete, S. Bua, F.A.S. Alasmary, Z. AlOthman, S. Tambutte, D. Zoccola, C.T. Supuran, C. Capasso, Comparison of the Sulfonamide Inhibition Profiles of the alpha-Carbonic Anhydrase Isoforms (SpiCA1, SpiCA2 and SpiCA3) Encoded by the Genome of the Scleractinian Coral Stylophora pistillata, Mar Drugs 17(3) (2019).

[23] S. Bua, S.M. Osman, S. Del Prete, C. Capasso, Z. AlOthman, A. Nocentini, C.T. Supuran, Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae, Bioorg Chem 86 (2019) 183-186.

[24] A. Angeli, M. Pinteala, S.S. Maier, S. Del Prete, C. Capasso, B.C. Simionescu, C.T. Supuran, Inhibition of alpha-, beta-, gamma-, delta-, zeta- and eta-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine, J Enzyme Inhib Med Chem 34(1) (2019) 644-650.

[25] A. Angeli, M. Pinteala, S.S. Maier, S. Del Prete, C. Capasso, B.C. Simionescu, C.T. Supuran, Inhibition of bacterial alpha-, beta- and gamma-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties, J Enzyme Inhib Med Chem 34(1) (2019) 244-249.

[26] A. Angeli, S. Del Prete, M. Pinteala, S.S. Maier, W.A. Donald, B.C. Simionescu, C. Capasso, C.T. Supuran, The first activation study of the beta-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids, J Enzyme Inhib Med Chem 34(1) (2019) 1178-1185.

[27] A. Angeli, S. Del Prete, S.M. Osman, Z. AlOthman, W.A. Donald, C. Capasso, C.T. Supuran, Activation Studies of the gamma-Carbonic Anhydrases from the Antarctic Marine Bacteria Pseudoalteromonas haloplanktis and Colwellia psychrerythraea with Amino Acids and Amines, Mar Drugs 17(4) (2019).

[28] D. Vullo, S. Del Prete, S.M. Osman, F.A.S. Alasmary, Z. AlOthman, W.A. Donald, C. Capasso, C.T. Supuran, Comparison of the amine/amino acid activation profiles of the beta- and gamma-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei, J Enzyme Inhib Med Chem 33(1) (2018) 25-30.

[29] C.T. Supuran, C. Capasso, Biomedical applications of prokaryotic carbonic anhydrases, Expert Opin Ther Pat 28(10) (2018) 745-754.

[30] A. Stefanucci, A. Angeli, M.P. Dimmito, G. Luisi, S. Del Prete, C. Capasso, W.A. Donald, A. Mollica, C.T. Supuran, Activation of beta- and gamma-carbonic anhydrases from pathogenic bacteria with tripeptides, J Enzyme Inhib Med Chem 33(1) (2018) 945-950.

[31] A. Nocentini, S. Bua, S. Del Prete, Y.E. Heravi, A.A. Saboury, A. Karioti, A.R. Bilia, C. Capasso, P. Gratteri, C.T. Supuran, Natural Polyphenols Selectively Inhibit beta-Carbonic Anhydrase from the Dandruff-Producing Fungus Malassezia globosa: Activity and Modeling Studies, ChemMedChem 13(8) (2018) 816-823.

[32] C. Melis, S. Distinto, G. Bianco, R. Meleddu, F. Cottiglia, B. Fois, D. Taverna, R. Angius, S. Alcaro, F. Ortuso, M. Gaspari, A. Angeli, S. Del Prete, C. Capasso, C.T. Supuran, E. Maccioni, Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors, ACS Med Chem Lett 9(7) (2018) 725-729.

[33] R. Meleddu, S. Distinto, F. Cottiglia, R. Angius, M. Gaspari, D. Taverna, C. Melis, A. Angeli, G. Bianco, S. Deplano, B. Fois, S. Del Prete, C. Capasso, S. Alcaro, F. Ortuso, M. Yanez, C.T. Supuran, E. Maccioni, Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides, ACS Med Chem Lett 9(10) (2018) 1045-1050.

[34] S. Del Prete, D. Vullo, N. Caminiti-Segonds, D. Zoccola, S. Tambutte, C.T. Supuran, C. Capasso, Protonography and anion inhibition profile of the alpha-carbonic anhydrase (CruCA4) identified in the Mediterranean red coral Corallium rubrum, Bioorg Chem 76 (2018) 281-287.

[35] S. Del Prete, S. Bua, D. Zoccola, F.A.S. Alasmary, Z. AlOthman, L.S. Alqahtani, N. Techer, C.T. Supuran, S. Tambutte, C. Capasso, Comparison of the Anion Inhibition Profiles of the alpha-CA Isoforms (SpiCA1, SpiCA2 and SpiCA3) from the Scleractinian Coral Stylophora pistillata, Int J Mol Sci 19(7) (2018).

[36] L. De Luca, F. Mancuso, S. Ferro, M.R. Buemi, A. Angeli, S. Del Prete, C. Capasso, C.T. Supuran, R. Gitto, Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases, Eur J Med Chem 143 (2018) 276-282.

[37] S. Bua, M. Bozdag, S. Del Prete, F. Carta, W.A. Donald, C. Capasso, C.T. Supuran, Mono- and di-thiocarbamate inhibition studies of the delta-carbonic anhydrase TweCAdelta from the marine diatom Thalassiosira weissflogii, J Enzyme Inhib Med Chem 33(1) (2018) 707-713.

[38] S. Bua, E. Berrino, S. Del Prete, V.S. Murthy, V. Vijayakumar, Y. Tamboli, C. Capasso, E. Cerbai, A. Mugelli, F. Carta, C.T. Supuran, Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae alpha- and beta-class enzymes, J Enzyme Inhib Med Chem 33(1) (2018) 1125-1136.

[39] E. Berrino, M. Bozdag, S. Del Prete, F.A.S. Alasmary, L.S. Alqahtani, Z. AlOthman, C. Capasso, C.T. Supuran, Inhibition of alpha-, beta-, gamma-, and delta-carbonic anhydrases from bacteria and diatoms with N’-aryl-N-hydroxy-ureas, J Enzyme Inhib Med Chem 33(1) (2018) 1194-1198.

[40] G. Annunziato, L. Giovati, A. Angeli, M. Pavone, S. Del Prete, M. Pieroni, C. Capasso, A. Bruno, S. Conti, W. Magliani, C.T. Supuran, G. Costantino, Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases, J Enzyme Inhib Med Chem 33(1) (2018) 1537-1544.

[41] A. Angeli, S. Del Prete, S.M. Osman, F.A.S. Alasmary, Z. AlOthman, W.A. Donald, C. Capasso, C.T. Supuran, Activation studies of the alpha- and beta-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids, J Enzyme Inhib Med Chem 33(1) (2018) 227-233.

[42] A. Angeli, S. Del Prete, S.M. Osman, F.A.S. Alasmary, Z. AlOthman, W.A. Donald, C. Capasso, C.T. Supuran, Activation studies with amines and amino acids of the beta-carbonic anhydrase encoded by the Rv3273 gene from the pathogenic bacterium Mycobacterium tuberculosis, J Enzyme Inhib Med Chem 33(1) (2018) 364-369.

[43] A. Angeli, S. Del Prete, W.A. Donald, C. Capasso, C.T. Supuran, The gamma-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae is potently activated by amines and amino acids, Bioorg Chem 77 (2018) 1-5.

[44] A. Angeli, S. Del Prete, F.A.S. Alasmary, L.S. Alqahtani, Z. AlOthman, W.A. Donald, C. Capasso, C.T. Supuran, The first activation studies of the eta-carbonic anhydrase from the malaria parasite Plasmodium falciparum with amines and amino acids, Bioorg Chem 80 (2018) 94-98.

[45] A. Angeli, F.A.S. Alasmary, S. Del Prete, S.M. Osman, Z. AlOthman, W.A. Donald, C. Capasso, C.T. Supuran, The first activation study of a delta-carbonic anhydrase: TweCAdelta from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids, J Enzyme Inhib Med Chem 33(1) (2018) 680-685.

[46] A. Angeli, G. Abbas, S. Del Prete, C. Capasso, C.T. Supuran, Selenides bearing benzenesulfonamide show potent inhibition activity against carbonic anhydrases from pathogenic bacteria Vibrio cholerae and Burkholderia pseudomallei, Bioorg Chem 79 (2018) 319-322.

[47] D. Vullo, S. Del Prete, S.M. Osman, Z. AlOthman, C. Capasso, W.A. Donald, C.T. Supuran, Burkholderia pseudomallei gamma-carbonic anhydrase is strongly activated by amino acids and amines, Bioorg Med Chem Lett 27(1) (2017) 77-80.

[48] D. Vullo, S. Del Prete, A. Nocentini, S.M. Osman, Z. AlOthman, C. Capasso, M. Bozdag, F. Carta, P. Gratteri, C.T. Supuran, Dithiocarbamates effectively inhibit the beta-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa, Bioorg Med Chem 25(3) (2017) 1260-1265.

[49] D. Vullo, S. Del Prete, P. Di Fonzo, V. Carginale, W.A. Donald, C.T. Supuran, C. Capasso, Comparison of the Sulfonamide Inhibition Profiles of the beta- and gamma-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei, Molecules 22(3) (2017).

[50] C.T. Supuran, C. Capasso, Carbonic Anhydrase from Porphyromonas Gingivalis as a Drug Target, Pathogens 6(3) (2017).

[51] C.T. Supuran, C. Capasso, An Overview of the Bacterial Carbonic Anhydrases, Metabolites 7(4) (2017).

[52] R. Perfetto, S. Del Prete, D. Vullo, G. Sansone, C.M.A. Barone, M. Rossi, C.T. Supuran, C. Capasso, Production and covalent immobilisation of the recombinant bacterial carbonic anhydrase (SspCA) onto magnetic nanoparticles, J Enzyme Inhib Med Chem 32(1) (2017) 759-766.

[53] R. Perfetto, S. Del Prete, D. Vullo, G. Sansone, C.M.A. Barone, M. Rossi, C.T. Supuran, C. Capasso, Sequence Analysis, Kinetic Constants, and Anion Inhibition Profile of the Nacrein-Like Protein (CgiNAP2X1) from the Pacific Oyster Magallana gigas (Ex-Crassostrea gigas), Mar Drugs 15(9) (2017).

[54] R. Perfetto, S. Del Prete, D. Vullo, G. Sansone, C. Barone, M. Rossi, C.T. Supuran, C. Capasso, Biochemical characterization of the native alpha-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilus galloprovincialis, J Enzyme Inhib Med Chem 32(1) (2017) 632-639.

[55] R. Perfetto, S. Del Prete, D. Vullo, V. Carginale, G. Sansone, C.M.A. Barone, M. Rossi, F.A.S. Alasmary, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Cloning, expression and purification of the alpha-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis, J Enzyme Inhib Med Chem 32(1) (2017) 1029-1035.

[56] A. Nocentini, D. Vullo, S. Del Prete, S.M. Osman, F.A.S. Alasmary, Z. AlOthman, C. Capasso, F. Carta, P. Gratteri, C.T. Supuran, Inhibition of the beta-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates, J Enzyme Inhib Med Chem 32(1) (2017) 1064-1070.

[57] A. Nocentini, R. Cadoni, S. Del Prete, C. Capasso, P. Dumy, P. Gratteri, C.T. Supuran, J.Y. Winum, Benzoxaboroles as Efficient Inhibitors of the beta-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study, ACS Med Chem Lett 8(11) (2017) 1194-1198.

[58] C. Melis, R. Meleddu, A. Angeli, S. Distinto, G. Bianco, C. Capasso, F. Cottiglia, R. Angius, C.T. Supuran, E. Maccioni, Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors, J Enzyme Inhib Med Chem 32(1) (2017) 68-73.

[59] R. Kumar, S. Bua, S. Ram, S. Del Prete, C. Capasso, C.T. Supuran, P.K. Sharma, Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors, Bioorg Med Chem 25(3) (2017) 1286-1293.

[60] G.M. Fisher, S. Bua, S. Del Prete, M.S. Arnold, C. Capasso, C.T. Supuran, K.T. Andrews, S.A. Poulsen, Investigating the antiplasmodial activity of primary sulfonamide compounds identified in open source malaria data, Int J Parasitol Drugs Drug Resist 7(1) (2017) 61-70.

[61] Y. Entezari Heravi, S. Bua, A. Nocentini, S. Del Prete, A.A. Saboury, H. Sereshti, C. Capasso, P. Gratteri, C.T. Supuran, Inhibition of Malassezia globosa carbonic anhydrase with phenols, Bioorg Med Chem 25(9) (2017) 2577-2582.

[62] S. Del Prete, D. Vullo, D. Zoccola, S. Tambutte, C.T. Supuran, C. Capasso, Activation Profile Analysis of CruCA4, an alpha-Carbonic Anhydrase Involved in Skeleton Formation of the Mediterranean Red Coral, Corallium rubrum, Molecules 23(1) (2017).

[63] S. Del Prete, D. Vullo, D. Zoccola, S. Tambutte, C. Capasso, C.T. Supuran, Kinetic properties and affinities for sulfonamide inhibitors of an alpha-carbonic anhydrase (CruCA4) involved in coral biomineralization in the Mediterranean red coral Corallium rubrum, Bioorg Med Chem 25(13) (2017) 3525-3530.

[64] S. Del Prete, D. Vullo, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Sulfonamide inhibition profiles of the beta-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia, Bioorg Med Chem 25(13) (2017) 3555-3561.

[65] S. Del Prete, D. Vullo, S.M. Osman, Z. AlOthman, W.A. Donald, J.Y. Winum, C.T. Supuran, C. Capasso, Anion inhibitors of the beta-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis, Bioorg Med Chem 25(17) (2017) 4800-4804.

[66] S. Del Prete, D. Vullo, P. Di Fonzo, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Anion inhibition profiles of the gamma-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics, Bioorg Med Chem 25(2) (2017) 575-580.

[67] S. Del Prete, D. Vullo, P. Di Fonzo, S.M. Osman, Z. AlOthman, W.A. Donald, C.T. Supuran, C. Capasso, Sulfonamide inhibition profile of the gamma-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis, Bioorg Med Chem Lett 27(3) (2017) 490-495.

[68] S. Del Prete, D. Vullo, P. di Fonzo, V. Carginale, C.T. Supuran, C. Capasso, Comparison of the anion inhibition profiles of the beta- and gamma-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei, Bioorg Med Chem 25(6) (2017) 2010-2015.

[69] S. Del Prete, R. Perfetto, M. Rossi, F.A.S. Alasmary, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, A one-step procedure for immobilising the thermostable carbonic anhydrase (SspCA) on the surface membrane of Escherichia coli, J Enzyme Inhib Med Chem 32(1) (2017) 1120-1128.

[70] D. De Vita, A. Angeli, F. Pandolfi, M. Bortolami, R. Costi, R. Di Santo, E. Suffredini, M. Ceruso, S. Del Prete, C. Capasso, L. Scipione, C.T. Supuran, Inhibition of the alpha-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties, J Enzyme Inhib Med Chem 32(1) (2017) 798-804.

[71] C. Capasso, C.T. Supuran, Inhibition of Bacterial Carbonic Anhydrases as a Novel Approach to Escape Drug Resistance, Curr Top Med Chem 17(11) (2017) 1237-1248.

[72] A. Angeli, G. Abbas, S. Del Prete, F. Carta, C. Capasso, C.T. Supuran, Acyl selenoureido benzensulfonamides show potent inhibitory activity against carbonic anhydrases from the pathogenic bacterium Vibrio cholerae, Bioorg Chem 75 (2017) 170-172.

[73] S. Angapelly, P.V.S. Ramya, A. Angeli, S. Del Prete, C. Capasso, M. Arifuddin, C.T. Supuran, Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors, Bioorg Med Chem 25(20) (2017) 5726-5732.

[74] D. Vullo, S. Del Prete, V. De Luca, V. Carginale, M. Ferraroni, N. Dedeoglu, S.M. Osman, Z. AlOthman, C. Capasso, C.T. Supuran, Anion inhibition studies of the beta-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae, Bioorg Med Chem Lett 26(5) (2016) 1406-10.

[75] D. Vullo, S. Del Prete, C. Capasso, C.T. Supuran, Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from Malassezia globosa with amines and amino acids, Bioorg Med Chem Lett 26(5) (2016) 1381-5.

[76] D. Vullo, V. De Luca, S. Del Prete, V. Carginale, A. Scozzafava, S.M. Osman, Z. AlOthman, C. Capasso, C.T. Supuran, Sulfonamide inhibition studies of the gamma-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea, Bioorg Med Chem Lett 26(4) (2016) 1253-9.

[77] C.T. Supuran, C. Capasso, New light on bacterial carbonic anhydrases phylogeny based on the analysis of signal peptide sequences, J Enzyme Inhib Med Chem 31(6) (2016) 1254-60.

[78] O. Ozensoy Guler, C. Capasso, C.T. Supuran, A magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization, J Enzyme Inhib Med Chem 31(5) (2016) 689-94.

[79] S. Del Prete, D. Vullo, V. De Luca, V. Carginale, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Comparison of the sulfonamide inhibition profiles of the alpha-, beta- and gamma-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae, Bioorg Med Chem Lett 26(8) (2016) 1941-6.

[80] S. Del Prete, D. Vullo, V. De Luca, V. Carginale, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum, Bioorg Med Chem Lett 26(17) (2016) 4184-90.

[81] S. Del Prete, D. Vullo, V. De Luca, V. Carginale, M. Ferraroni, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Sulfonamide inhibition studies of the beta-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae, Bioorg Med Chem 24(5) (2016) 1115-20.

[82] S. Del Prete, D. Vullo, V. De Luca, V. Carginale, P. di Fonzo, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Anion inhibition profiles of alpha-, beta- and gamma-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae, Bioorg Med Chem 24(16) (2016) 3413-7.

[83] S. Del Prete, D. Vullo, V. De Luca, V. Carginale, P. di Fonzo, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Anion inhibition profiles of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum, Bioorg Med Chem 24(18) (2016) 4410-4414.

[84] S. Del Prete, V. De Luca, D. Vullo, S.M. Osman, Z. AlOthman, V. Carginale, C.T. Supuran, C. Capasso, A new procedure for the cloning, expression and purification of the beta-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target, J Enzyme Inhib Med Chem 31(6) (2016) 1156-61.

[85] S. Del Prete, V. De Luca, G. De Simone, C.T. Supuran, C. Capasso, Cloning, expression and purification of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum, J Enzyme Inhib Med Chem 31(sup4) (2016) 54-59.

[86] S. Del Prete, V. De Luca, C. Capasso, C.T. Supuran, V. Carginale, Recombinant thermoactive phosphoenolpyruvate carboxylase (PEPC) from Thermosynechococcus elongatus and its coupling with mesophilic/thermophilic bacterial carbonic anhydrases (CAs) for the conversion of CO2 to oxaloacetate, Bioorg Med Chem 24(2) (2016) 220-5.

[87] V. De Luca, D. Vullo, S. Del Prete, V. Carginale, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Cloning, characterization and anion inhibition studies of a gamma-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea, Bioorg Med Chem 24(4) (2016) 835-40.

[88] V. De Luca, S. Del Prete, D. Vullo, V. Carginale, P. Di Fonzo, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Expression and characterization of a recombinant psychrophilic gamma-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc, J Enzyme Inhib Med Chem 31(5) (2016) 810-7.

[89] C. Capasso, C.T. Supuran, An Overview of the Carbonic Anhydrases from Two Pathogens of the Oral Cavity: Streptococcus mutans and Porphyromonas gingivalis, Curr Top Med Chem 16(21) (2016) 2359-68.

[90] G. Annunziato, A. Angeli, F. D’Alba, A. Bruno, M. Pieroni, D. Vullo, V. De Luca, C. Capasso, C.T. Supuran, G. Costantino, Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches, ChemMedChem 11(17) (2016) 1904-14.

[91] N.M. Abdel Gawad, N.H. Amin, M.T. Elsaadi, F.M.M. Mohamed, A. Angeli, V. De Luca, C. Capasso, C.T. Supuran, Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines, Bioorg Med Chem 24(13) (2016) 3043-3051.

[92] D. Vullo, S. Del Prete, G.M. Fisher, K.T. Andrews, S.A. Poulsen, C. Capasso, C.T. Supuran, Sulfonamide inhibition studies of the eta-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum, Bioorg Med Chem 23(3) (2015) 526-31.

[93] D. Vullo, V. De Luca, S. Del Prete, V. Carginale, A. Scozzafava, C. Capasso, C.T. Supuran, Sulfonamide inhibition studies of the gamma-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune, Bioorg Med Chem 23(8) (2015) 1728-34.

[94] D. Vullo, V. De Luca, S. Del Prete, V. Carginale, A. Scozzafava, C. Capasso, C.T. Supuran, Sulfonamide inhibition studies of the gamma-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis, Bioorg Med Chem Lett 25(17) (2015) 3550-5.

[95] C.T. Supuran, C. Capasso, The eta-class carbonic anhydrases as drug targets for antimalarial agents, Expert Opin Ther Targets 19(4) (2015) 551-63.

[96] M. Ferraroni, S. Del Prete, D. Vullo, C. Capasso, C.T. Supuran, Crystal structure and kinetic studies of a tetrameric type II beta-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae, Acta Crystallogr D Biol Crystallogr 71(Pt 12) (2015) 2449-56.

[97] S. Del Prete, D. Vullo, S.M. Osman, Z. AlOthman, C. Capasso, C.T. Supuran, Anion inhibition studies of the dandruff-producing fungus Malassezia globosa beta-carbonic anhydrase MgCA, Bioorg Med Chem Lett 25(22) (2015) 5194-8.

[98] S. Del Prete, D. Vullo, V. De Luca, Z. AlOthman, S.M. Osman, C.T. Supuran, C. Capasso, Biochemical characterization of recombinant beta-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis, J Enzyme Inhib Med Chem 30(3) (2015) 366-70.

[99] S. Del Prete, V. De Luca, C.T. Supuran, C. Capasso, Protonography, a technique applicable for the analysis of eta-carbonic anhydrase activity, J Enzyme Inhib Med Chem 30(6) (2015) 920-4.

[100] S. Del Prete, V. De Luca, E. Iandolo, C.T. Supuran, C. Capasso, Protonography, a powerful tool for analyzing the activity and the oligomeric state of the gamma-carbonic anhydrase identified in the genome of Porphyromonas gingivalis, Bioorg Med Chem 23(13) (2015) 3747-50.

[101] N. Dedeoglu, V. DeLuca, S. Isik, H. Yildirim, F. Kockar, C. Capasso, C.T. Supuran, Sulfonamide inhibition study of the beta-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans, Bioorg Med Chem Lett 25(11) (2015) 2291-7.

[102] N. Dedeoglu, V. De Luca, S. Isik, H. Yildirim, F. Kockar, C. Capasso, C.T. Supuran, Cloning, characterization and anion inhibition study of a beta-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans, Bioorg Med Chem 23(13) (2015) 2995-3001.

[103] G. De Simone, S.M. Monti, V. Alterio, M. Buonanno, V. De Luca, M. Rossi, V. Carginale, C.T. Supuran, C. Capasso, A. Di Fiore, Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense, Bioorg Med Chem Lett 25(9) (2015) 2002-6.

[104] G. De Simone, A. Di Fiore, C. Capasso, C.T. Supuran, The zinc coordination pattern in the eta-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families, Bioorg Med Chem Lett 25(7) (2015) 1385-9.

[105] V. De Luca, D. Vullo, S. Del Prete, V. Carginale, A. Scozzafava, S.M. Osman, Z. AlOthman, C.T. Supuran, C. Capasso, Cloning, characterization and anion inhibition studies of a new gamma-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis, Bioorg Med Chem 23(15) (2015) 4405-9.

[106] V. De Luca, S. Del Prete, C.T. Supuran, C. Capasso, Protonography, a new technique for the analysis of carbonic anhydrase activity, J Enzyme Inhib Med Chem 30(2) (2015) 277-82.

[107] V. De Luca, S. Del Prete, V. Carginale, D. Vullo, C.T. Supuran, C. Capasso, A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes, J Enzyme Inhib Med Chem 30(6) (2015) 989-94.

[108] V. De Luca, S. Del Prete, V. Carginale, D. Vullo, C.T. Supuran, C. Capasso, Cloning, characterization and anion inhibition studies of a gamma-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune, Bioorg Med Chem Lett 25(21) (2015) 4970-4975.

[109] F. Carta, S.M. Osman, D. Vullo, Z. AlOthman, S. Del Prete, C. Capasso, C.T. Supuran, Poly(amidoamine) dendrimers show carbonic anhydrase inhibitory activity against alpha-, beta-, gamma- and eta-class enzymes, Bioorg Med Chem 23(21) (2015) 6794-8.

[110] C. Capasso, C.T. Supuran, An overview of the alpha-, beta- and gamma-carbonic anhydrases from Bacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?, J Enzyme Inhib Med Chem 30(2) (2015) 325-32.

[111] C. Capasso, C.T. Supuran, An Overview of the Selectivity and Efficiency of the Bacterial Carbonic Anhydrase Inhibitors, Curr Med Chem 22(18) (2015) 2130-9.

[112] C. Capasso, C.T. Supuran, Bacterial, fungal and protozoan carbonic anhydrases as drug targets, Expert Opin Ther Targets 19(12) (2015) 1689-704.

[113] M. Bejaoui, E. Pantazi, V. De Luca, A. Panisello, E. Folch-Puy, G. Hotter, C. Capasso, C.T. Supuran, J. Rosello-Catafau, Correction: Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage, PLoS One 10(9) (2015) e0139411.

[114] A.M. Alafeefy, M. Ceruso, A.M. Al-Tamimi, S. Del Prete, C.T. Supuran, C. Capasso, Inhibition studies of quinazoline-sulfonamide derivatives against the gamma-CA (PgiCA) from the pathogenic bacterium, Porphyromonas gingivalis, J Enzyme Inhib Med Chem 30(4) (2015) 592-6.

[115] A.M. Alafeefy, H.A. Abdel-Aziz, D. Vullo, A.M. Al-Tamimi, A.S. Awaad, M.A. Mohamed, C. Capasso, C.T. Supuran, Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-, [1.2,4]triazolo[3.4-b][1.3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1.3,4-thiadiazol-3(2H)-yl moieties, J Enzyme Inhib Med Chem 30(1) (2015) 52-6.

[116] D. Vullo, E.V. Kupriyanova, A. Scozzafava, C. Capasso, C.T. Supuran, Anion inhibition study of the beta-carbonic anhydrase (CahB1) from the cyanobacterium Coleofasciculus chthonoplastes (ex-Microcoleus chthonoplastes), Bioorg Med Chem 22(5) (2014) 1667-71.

[117] D. Vullo, E. Flemetakis, A. Scozzafava, C. Capasso, C.T. Supuran, Anion inhibition studies of two alpha-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2, J Inorg Biochem 136 (2014) 67-72.

[118] D. Vullo, S. Del Prete, S.M. Osman, A. Scozzafava, Z. Alothman, C.T. Supuran, C. Capasso, Anion inhibition study of the beta-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis, Bioorg Med Chem Lett 24(18) (2014) 4402-4406.

[119] D. Vullo, S. Del Prete, S.M. Osman, V. De Luca, A. Scozzafava, Z. Alothman, C.T. Supuran, C. Capasso, Sulfonamide inhibition studies of the delta-carbonic anhydrase from the diatom Thalassiosira weissflogii, Bioorg Med Chem Lett 24(1) (2014) 275-9.

[120] D. Vullo, S. Del Prete, S.M. Osman, V. De Luca, A. Scozzafava, Z. Alothman, C.T. Supuran, C. Capasso, Sulfonamide inhibition studies of the gamma-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, Bioorg Med Chem Lett 24(1) (2014) 240-4.

[121] G.C. Rodrigues, D.F. Feijo, M.T. Bozza, P. Pan, D. Vullo, S. Parkkila, C.T. Supuran, C. Capasso, A.P. Aguiar, A.B. Vermelho, Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease, J Med Chem 57(2) (2014) 298-308.

[122] S.D. Prete, D. Vullo, S.M. Osman, A. Scozzafava, Z. AlOthman, C. Capasso, C.T. Supuran, Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the beta-class (PgiCAb) versus the gamma-class (PgiCA) enzymes, Bioorg Med Chem 22(17) (2014) 4537-43.

[123] I. Nishimori, D. Vullo, T. Minakuchi, A. Scozzafava, S.M. Osman, Z. AlOthman, C. Capasso, C.T. Supuran, Anion inhibition studies of two new beta-carbonic anhydrases from the bacterial pathogen Legionella pneumophila, Bioorg Med Chem Lett 24(4) (2014) 1127-32.

[124] I. Nishimori, D. Vullo, T. Minakuchi, A. Scozzafava, C. Capasso, C.T. Supuran, Sulfonamide inhibition studies of two beta-carbonic anhydrases from the bacterial pathogen Legionella pneumophila, Bioorg Med Chem 22(11) (2014) 2939-46.

[125] F. Migliardini, V. De Luca, V. Carginale, M. Rossi, P. Corbo, C.T. Supuran, C. Capasso, Biomimetic CO2 capture using a highly thermostable bacterial alpha-carbonic anhydrase immobilized on a polyurethane foam, J Enzyme Inhib Med Chem 29(1) (2014) 146-50.

[126] S. Del Prete, D. Vullo, A. Scozzafava, C. Capasso, C.T. Supuran, Cloning, characterization and anion inhibition study of the delta-class carbonic anhydrase (TweCA) from the marine diatom Thalassiosira weissflogii, Bioorg Med Chem 22(1) (2014) 531-7.

[127] S. Del Prete, D. Vullo, G.M. Fisher, K.T. Andrews, S.A. Poulsen, C. Capasso, C.T. Supuran, Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the eta-carbonic anhydrases, Bioorg Med Chem Lett 24(18) (2014) 4389-4396.

[128] S. Del Prete, D. Vullo, V. De Luca, C.T. Supuran, C. Capasso, Biochemical characterization of the delta-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA, J Enzyme Inhib Med Chem 29(6) (2014) 906-11.

[129] S. Del Prete, V. De Luca, D. Vullo, A. Scozzafava, V. Carginale, C.T. Supuran, C. Capasso, Biochemical characterization of the gamma-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA, J Enzyme Inhib Med Chem 29(4) (2014) 532-7.

[130] S. Del Prete, V. De Luca, A. Scozzafava, V. Carginale, C.T. Supuran, C. Capasso, Biochemical properties of a new alpha-carbonic anhydrase from the human pathogenic bacterium, Vibrio cholerae, J Enzyme Inhib Med Chem 29(1) (2014) 23-7.

[131] M. Ceruso, S. Del Prete, Z. AlOthman, S.M. Osman, A. Scozzafava, C. Capasso, C.T. Supuran, Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis gamma-carbonic anhydrase, Bioorg Med Chem Lett 24(16) (2014) 4006-10.

[132] M. Ceruso, S. Del Prete, Z. Alothman, C. Capasso, C.T. Supuran, Sulfonamides with Potent Inhibitory Action and Selectivity against the alpha-Carbonic Anhydrase from Vibrio cholerae, ACS Med Chem Lett 5(7) (2014) 826-30.

[133] C. Capasso, C.T. Supuran, Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors, J Enzyme Inhib Med Chem 29(3) (2014) 379-87.

[134] S. Bilginer, E. Unluer, H.I. Gul, E. Mete, S. Isik, D. Vullo, O. Ozensoy-Guler, S. Beyaztas, C. Capasso, C.T. Supuran, Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae beta-carbonic anhydrase, J Enzyme Inhib Med Chem 29(4) (2014) 495-9.

[135] A.M. Alafeefy, M. Ceruso, A.M. Al-Tamimi, S. Del Prete, C. Capasso, C.T. Supuran, Quinazoline-sulfonamides with potent inhibitory activity against the alpha-carbonic anhydrase from Vibrio cholerae, Bioorg Med Chem 22(19) (2014) 5133-40.

[136] A.M. Alafeefy, H.A. Abdel-Aziz, D. Vullo, A.M. Al-Tamimi, N.A. Al-Jaber, C. Capasso, C.T. Supuran, Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1.2,4]triazolo[3.4-b][1.3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1.3,4-thiadiazol-3(2H)-yl moieties, Bioorg Med Chem 22(1) (2014) 141-7.

[137] D. Vullo, R.S. Sai Kumar, A. Scozzafava, C. Capasso, J.G. Ferry, C.T. Supuran, Anion inhibition studies of a beta-carbonic anhydrase from Clostridium perfringens, Bioorg Med Chem Lett 23(24) (2013) 6706-10.

[138] D. Vullo, V.D. Luca, A. Scozzafava, V. Carginale, M. Rossi, C.T. Supuran, C. Capasso, The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides, Bioorg Med Chem 21(6) (2013) 1534-8.

[139] D. Vullo, W. Leewattanapasuk, F.A. Muhlschlegel, A. Mastrolorenzo, C. Capasso, C.T. Supuran, Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides, Bioorg Med Chem Lett 23(9) (2013) 2647-52.

[140] D. Vullo, S. Isik, S. Del Prete, V. De Luca, V. Carginale, A. Scozzafava, C.T. Supuran, C. Capasso, Anion inhibition studies of the alpha-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae, Bioorg Med Chem Lett 23(6) (2013) 1636-8.

[141] D. Vullo, V. De Luca, A. Scozzafava, V. Carginale, M. Rossi, C.T. Supuran, C. Capasso, The extremo-alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides, Bioorg Med Chem 21(15) (2013) 4521-5.

[142] L. Syrjanen, A.B. Vermelho, A. Rodrigues Ide, S. Corte-Real, T. Salonen, P. Pan, D. Vullo, S. Parkkila, C. Capasso, C.T. Supuran, Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis, J Med Chem 56(18) (2013) 7372-81.

[143] P. Pan, A.B. Vermelho, A. Scozzafava, S. Parkkila, C. Capasso, C.T. Supuran, Anion inhibition studies of the alpha-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease, Bioorg Med Chem 21(15) (2013) 4472-6.

[144] P. Pan, A.B. Vermelho, G. Capaci Rodrigues, A. Scozzafava, M.E. Tolvanen, S. Parkkila, C. Capasso, C.T. Supuran, Cloning, characterization, and sulfonamide and thiol inhibition studies of an alpha-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease, J Med Chem 56(4) (2013) 1761-71.

[145] I. Nishimori, D. Vullo, T. Minakuchi, A. Scozzafava, C. Capasso, C.T. Supuran, Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition, Bioorg Med Chem Lett 23(1) (2013) 256-60.

[146] S.M. Monti, G. De Simone, N.A. Dathan, M. Ludwig, D. Vullo, A. Scozzafava, C. Capasso, C.T. Supuran, Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis, Bioorg Med Chem Lett 23(6) (2013) 1626-30.

[147] V.D. Luca, D. Vullo, A. Scozzafava, V. Carginale, M. Rossi, C.T. Supuran, C. Capasso, An alpha-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction, Bioorg Med Chem 21(6) (2013) 1465-9.

[148] O. Guzel-Akdemir, A. Akdemir, P. Pan, A.B. Vermelho, S. Parkkila, A. Scozzafava, C. Capasso, C.T. Supuran, A class of sulfonamides with strong inhibitory action against the alpha-carbonic anhydrase from Trypanosoma cruzi, J Med Chem 56(14) (2013) 5773-81.

[149] A. Di Fiore, C. Capasso, V. De Luca, S.M. Monti, V. Carginale, C.T. Supuran, A. Scozzafava, C. Pedone, M. Rossi, G. De Simone, X-ray structure of the first extremo-alpha-carbonic anhydrase’, a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1, Acta Crystallogr D Biol Crystallogr 69(Pt 6) (2013) 1150-9.

[150] S. Del Prete, D. Vullo, V. De Luca, V. Carginale, A. Scozzafava, C.T. Supuran, C. Capasso, A highly catalytically active gamma-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules, Bioorg Med Chem Lett 23(14) (2013) 4067-71.

[151] C. Capasso, C.T. Supuran, Anti-infective carbonic anhydrase inhibitors: a patent and literature review, Expert Opin Ther Pat 23(6) (2013) 693-704.

[152] A.M. Alafeefy, S. Isik, N.A. Al-Jaber, D. Vullo, H.A. Abdel-Aziz, A.E. Ashour, A.S. Awaad, C. Capasso, C.T. Supuran, Carbonic anhydrase inhibitors. Benzenesulfonamides incorporating cyanoacrylamide moieties strongly inhibit Saccharomyces cerevisiae beta-carbonic anhydrase, Bioorg Med Chem Lett 23(12) (2013) 3570-5.

[153] A. Akdemir, D. Vullo, V. De Luca, A. Scozzafava, V. Carginale, M. Rossi, C.T. Supuran, C. Capasso, The extremo-alpha-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines, Bioorg Med Chem Lett 23(4) (2013) 1087-90.

[154] A. Akdemir, O. Guzel-Akdemir, A. Scozzafava, C. Capasso, C.T. Supuran, Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides, Bioorg Med Chem 21(17) (2013) 5228-32.

[155] D. Vullo, V. De Luca, A. Scozzafava, V. Carginale, M. Rossi, C.T. Supuran, C. Capasso, The first activation study of a bacterial carbonic anhydrase (CA). The thermostable alpha-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines, Bioorg Med Chem Lett 22(20) (2012) 6324-7.

[156] D. Vullo, V. De Luca, A. Scozzafava, V. Carginale, M. Rossi, C.T. Supuran, C. Capasso, Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense, Bioorg Med Chem Lett 22(23) (2012) 7142-5.

[157] S. Del Prete, S. Isik, D. Vullo, V. De Luca, V. Carginale, A. Scozzafava, C.T. Supuran, C. Capasso, DNA cloning, characterization, and inhibition studies of an alpha-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae, J Med Chem 55(23) (2012) 10742-8.

[158] V. De Luca, D. Vullo, A. Scozzafava, V. Carginale, M. Rossi, C.T. Supuran, C. Capasso, Anion inhibition studies of an alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1, Bioorg Med Chem Lett 22(17) (2012) 5630-4.

Selected Publications

(full list available at CNR People)

Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases

Abdoli M, De Luca V, Capasso C, Supuran CT, Zalubovskis R

Year: 2023

Investigation of carbonic anhydrase inhibitory potency of ( Z/E )-alkyl N’-benzyl- N -(arylsulfonyl)-carbamimidothioates

Abdoli M, Luca VD, Capasso C, Supuran CT, Zalubovskis R

Year: 2023

Synthesis, Biological and In Silico Studies of Griseofulvin and Usnic Acid Sulfonamide Derivatives as Fungal, Bacterial and Human Carbonic Anhydrase Inhibitors

Angeli A, Petrou A, Kartsev V, Lichitsky B, Komogortsev A, Capasso C, Geronikaki A, Supuran CT

Year: 2023

The management of Babesia , amoeba and other zoonotic diseases provoked by protozoa

Capasso C, Supuran CT

Year: 2023

Photoactivatable Heptamethine-Based Carbonic Anhydrase Inhibitors Leading to New Anti-Antibacterial Agents

Carradori S, Angeli A, Sfragano PS, Yzeiri X, Calamante M, Tanini D, Capperucci A, Kunstek H, Varbanov M, Capasso C, Supuran CT

Year: 2023

Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships

Fantacuzzi M, D’agostino I, Carradori S, Liguori F, Carta F, Agamennone M, Angeli A, Sannio F, Docquier JD, Capasso C, Supuran CT

Year: 2023

Inhibition studies with simple and complex (in)organic anions of the γ-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri, MscCAγ

Giovannuzzi S, De Luca V, Capasso C, Supuran CT

Year: 2023

CARBONIC ANHYDRASE AS AN INDUSTRIAL BIOCATALYST FOR CCUS

Maria Elena Russo, Clemente Capasso, Antonio Marzocchella and Piero Salatino

Year: 2023

Antimicrobial and Antibiofilm Activities of Carvacrol, Amoxicillin and Salicylhydroxamic Acid Alone and in Combination vs. Helicobacter pylori: Towards a New Multi-Targeted Therapy

Puca V, Turacchio G, Marinacci B, Supuran CT, Capasso C, Di Giovanni P, D’agostino I, Carradori S, Grande R

Year: 2023

Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases

Abdoli M, De Luca V, Capasso C, Supuran CT, Åàalubovskis R

Year: 2022

Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase

Angeli A, UrbaÅàski LJ, Capasso C, Parkkila S, Supuran CT

Year: 2022

Seleno Containing Compounds as Potent and Selective Antifungal Agents

Angeli A, Velluzzi A, Selleri S, Capasso C, Spadini C, Iannarelli M, Cabassi CS, Carta F, Supuran CT

Year: 2022

Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen malassezia pachydermatis

De Luca V, Angeli A, Mazzone V, Adelfio C, Carginale V, Scaloni A, Carta F, Selleri S, Supuran CT, Capasso C

Year: 2022

The gram-negative bacterium Escherichia coli as a model for testing the effect of carbonic anhydrase inhibition on bacterial growth

De Luca V, Carginale V, Supuran CT, Capasso C

Year: 2022

May Sulfonamide Inhibitors of Carbonic Anhydrases from Mammaliicoccus sciuri Prevent Antimicrobial Resistance Due to Gene Transfer to Other Harmful Staphylococci?

De Luca V, Giovannuzzi S, Supuran CT, Capasso C

Year: 2022

Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII

Giovannuzzi S, Capasso C, Nocentini A, Supuran CT

Year: 2022

Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum

Giovannuzzi S, De Luca V, Nocentini A, Capasso C, Supuran CT

Year: 2022

Inhibition studies of bacterial α-carbonic anhydrases with phenols

Giovannuzzi S, Hewitt CS, Nocentini A, Capasso C, Costantino G, Flaherty DP, Supuran CT

Year: 2022

A comparative study of carbonic anhydrase activity in lymphocytes from colorectal cancer tissues and adjacent healthy counterparts

Nannini G, De Luca V, D’ambrosio C, Scaloni A, Taddei A, Ringressi MN, Cianchi F, Staderini F, Capasso C, Amedei A, Supuran CT

Year: 2022

Perspectives on the design and discovery of α-ketoamide inhibitors for the treatment of novel coronavirus: where do we stand and where do we go?

Nocentini A, Capasso C, Supuran CT

Year: 2022

Taurultams incorporating arylsulfonamide: First inàvitro inhibition studies of α-, β- and γ-class Carbonic Anhydrases from Vibrio cholerae and Burkholderia pseudomallei

Akgul O, Angeli A, Selleri S, Capasso C, Supuran CT, Carta F

Year: 2021

Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?

Amedei A, Capasso C, Nannini G, Supuran CT

Year: 2021

Response to perspectives on the classical enzyme carbonic anhydrase and the search for inhibitors

Angeli A, Carta F, Nocentini A, Winum JY, Zalubovskis R, Onnis V, Eldehna WM, Capasso C, Carradori S, Donald WA, Dedhar S, Supuran CT

Year: 2021

Carbonic anhydrases: new perspectives on protein functional role and inhibition in Helicobacter pylori

Campestre C, De Luca V, Carradori S, Grande R, Carginale V, Scaloni A, Supuran CT, Capasso C

Year: 2021

Inhibitory Effects of Sulfonamide Derivatives on the β-Carbonic Anhydrase (MpaCA) from Malassezia pachydermatis, a Commensal, Pathogenic Fungus Present in Domestic Animals

De Luca V, Angeli A, Mazzone V, Adelfio C, Carta F, Selleri S, Carginale V, Scaloni A, Supuran CT, Capasso C

Year: 2021

Effect of sulfonamides and their structurally related derivatives on the activity of ι-Carbonic Anhydrase from Burkholderia territorii

De Luca V, Petreni A, Nocentini A, Scaloni A, Supuran CT, Capasso C

Year: 2021

Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?

Deniz S, Uysal TK, Capasso C, Supuran CT, Ozensoy Guler O

Year: 2021

Selective Inhibition of Helicobacter pylori Carbonic Anhydrases by Carvacrol and Thymol Could Impair Biofilm Production and the Release of Outer Membrane Vesicles

Grande R, Carradori S, Puca V, Vitale I, Angeli A, Nocentini A, Bonardi A, Gratteri P, Lanuti P, Bologna G, Simeone P, Capasso C, De Luca V, Supuran CT

Year: 2021

4-Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae

Mancuso F, De Luca L, Bucolo F, Vrabel M, Angeli A, Capasso C, Supuran CT, Gitto R

Year: 2021

4-Sulfamoylphenylalkylamides as inhibitors of carbonic anhydrases expressed in Vibrio cholerae

Mancuso F, De Luca L, Bucolo F, Vrabel M, Angeli A, Capasso C, Supuran CT, Gitto R

Year: 2021

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

Nocentini A, Angeli A, Carta F, Winum JY, Zalubovskis R, Carradori S, Capasso C, Donald WA, Supuran CT

Year: 2021

Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017-present)

Nocentini A, Capasso C, Supuran CT

Year: 2021

An overview on the recently discovered iota-carbonic anhydrases

Nocentini A, Supuran CT, Capasso C

Year: 2021

Phenols from Origanum dictamnus L. and Thymus vulgaris L. and their activity against Malassezia globosa carbonic anhydrase

Paloukopoulou C, Govari S, Soulioti A, Stefanis I, Angeli A, Matheeussen A, Capasso C, Cos P, Supuran CT, Karioti A

Year: 2021

Evaluating the efficiency of enzyme accelerated CO₂ capture: chemical kinetics modelling for interpreting measurement results

Parri L, Fort A, Lo Grasso A, Mugnaini M, Vignoli V, Capasso C, Del Prete S, Romanelli MN, Supuran CT

Year: 2021

Anion inhibition studies of the Zn(II)-bound ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii

Petreni A, De Luca V, Scaloni A, Nocentini A, Capasso C, Supuran CT

Year: 2021

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors

Shaldam M, Eldehna WM, Nocentini A, Elsayed ZM, Ibrahim TM, Salem R, El-Domany RA, Capasso C, Abdel-Aziz HA, Supuran CT

Year: 2021

Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors

Shaldam M, Nocentini A, Elsayed ZM, Ibrahim TM, Salem R, El-Domany RA, Capasso C, Supuran CT, Eldehna WM

Year: 2021

A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium

Supuran CT, Capasso C

Year: 2021

Benzylaminoethylureido-tailed benzenesulfonamides show potent inhibitory activity against bacterial carbonic anhydrases

Ali M, Angeli A, Bozdag M, Carta F, Capasso C, Farooq U, Supuran CT

Year: 2020

Benzylaminoethylureido‐tailed Benzenesulfonamides show potent inhibitory activity against bacterial carbonic anhydrases

Ali M, Angeli A, Bozdag M, Carta F, Capasso C, Farooq U, Supuran CT

Year: 2020

Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom Thalassiosira weissflogii and protozoan Plasmodium falciparum

Alissa SA, Alghulikah HA, Alothman ZA, Osman SM, Del Prete S, Capasso C, Nocentini A, Supuran CT

Year: 2020

Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa

Alissa SA, Alghulikah HA, Alothman ZA, Osman SM, Del Prete S, Capasso C, Nocentini A, Supuran CT

Year: 2020

Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment

Angeli A, Carta F, Nocentini A, Winum JY, Zalubovskis R, Akdemir A, Onnis V, Eldehna WM, Capasso C, Simone GD, Monti SM, Carradori S, Donald WA, Dedhar S, Supuran CT

Year: 2020

Crystal structure of a tetrameric type II β-Carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei

Angeli A, Ferraroni M, Pinteala M, Maier SS, Simionescu BC, Carta F, Del Prete S, Capasso C, Supuran CT

Year: 2020

Evaluation of thio- and seleno-acetamides bearing benzenesulfonamide as inhibitor of carbonic anhydrases from different pathogenic bacteria

Angeli A, Pinteala M, Maier SS, Simionescu BC, Milaneschi A, Abbas G, del Prete S, Capasso C, Capperucci A, Tanini D, Carta F, Supuran CT

Year: 2020

Activation studies of the ?-carbonic anhydrases from Malassezia restricta with amines and amino acids" in "Activation studies of the beta-carbonic anhydrases from Malassezia restricta with amines and amino acids"

Angeli A, Prete SD, Ghobril C, Hitce J, Clavaud C, Marrat X, Donald WA, Capasso C, Supuran CT

Year: 2020

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

Aspatwar A, Berrino E, Bua S, Carta F, Capasso C, Parkkila S, Supuran CT

Year: 2020

Carbonic anhydrase modulation of emotional memory. Implications for the treatment of cognitive disorders

Blandina P, Provensi G, Passani MB, Capasso C, Supuran CT

Year: 2020

Benzoxaboroles: new potent inhibitors of the carbonic anhydrases of the pathogenic bacterium Vibrio cholerae

Bonardi A, Nocentini A, Cadoni R, del Prete S, Dumy P, Capasso C, Gratteri P, Supuran CT, Winum JY

Year: 2020

Protease inhibitors targeting the main protease and papain-like protease of coronaviruses

Capasso C, Nocentini A, Supuran CT

Year: 2020

Dihydropteroate synthase (sulfonamides) and dihydrofolate reductase inhibitors

Capasso C, Supuran CT

Year: 2020

Sulfonamide inhibition profile of the β-Carbonic Anhydrase from Malassezia restricta, an opportunistic pathogen triggering scalp conditions

Del Prete S, Angeli A, Ghobril C, Hitce J, Clavaud C, Marat X, Supuran CT, Capasso C

Year: 2020

Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors

Del Prete S, Bua S, Supuran CT, Capasso C

Year: 2020

The effect of substituted benzene-sulfonamides and clinically licensed drugs on the catalytic activity of CynT2, a carbonic anhydrase crucial for Escherichia coli life cycle

Del Prete S, De Luca V, Bua S, Nocentini A, Carginale V, Supuran CT, Capasso C

Year: 2020

Anion inhibition studies of the beta-carbonic anhydrase from Escherichia coli

Del Prete S, De Luca V, Nocentini A, Scaloni A, Mastrolorenzo MD, Supuran CT, Capasso C

Year: 2020

Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii

Del Prete S, Nocentini A, Supuran CT, Capasso C

Year: 2020

Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

Logozzi M, Mizzoni D, Capasso C, Del Prete S, Di Raimo R, Falchi M, Angelini DF, Sciarra A, Maggi M, Supuran CT, Fais S

Year: 2020

In silico-guided identification of new potent inhibitors of carbonic anhydrases expressed in Vibrio cholerae

Mancuso F, De Luca L, Angeli A, Berrino E, Del Prete S, Capasso C, Supuran CT, Gitto R

Year: 2020

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII

Mancuso F, De Luca L, Angeli A, Del Prete S, Capasso C, Supuran CT, Gitto R

Year: 2020

A deadly spillover: SARS-CoV-2 outbreak

Mori M, Capasso C, Carta F, Donald Wa, Supuran CT

Year: 2020

Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines

Nocentini A, Del Prete S, Mastrolorenzo MD, Donald WA, Capasso C, Supuran CT

Year: 2020

Carbonic anhydrase IX as a novel candidate in liquid biopsy

Ozensoy Guler O, Supuran CT, Capasso C

Year: 2020

Use of an immobilised thermostable α-CA (SspCA) for enhancing the metabolic efficiency of the freshwater green microalga Chlorella sorokiniana

Salbitani G, Del Prete S, Bolinesi F, Mangoni O, De Luca V, Carginale V, Donald WA, Supuran CT, Carfagna S, Capasso C

Year: 2020

Antibacterial carbonic anhydrase inhibitors: an update on the recent literature

Supuran CT, Capasso C

Year: 2020

Activation studies of the γ-carbonic anhydrases from the Antarctic marine bacteria Pseudoalteromonas haloplanktis and Colwellia psychrerythraea with amino acids and amines

Angeli A, Del Prete S, Osman SM, Alothman Z, Donald WA, Capasso C, Supuran CT

Year: 2019

The first activation study of the β-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids

Angeli A, Del Prete S, Pinteala M, Maier SS, Donald WA, Simionescu BC, Capasso C, Supuran CT

Year: 2019

Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine

Angeli A, Pinteala M, Maier SS, Del Prete S, Capasso C, Simionescu BC, Supuran CT

Year: 2019

Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae

Bua S, Osman SM, Del Prete S, Capasso C, Alothman Z, Nocentini A, Supuran CT

Year: 2019

Bacterial Resistance to Antibiotics: From Molecules to Man

Capasso C, Supuran CT

Year: 2019

Novel method of treating macular degeneration: a patent evaluation (WO2018/107005)

Capasso C, Winum JY

Year: 2019

Anion Inhibition Profile of the β-Carbonic Anhydrase from the Opportunist Pathogenic Fungus Malassezia Restricta Involved in Dandruff and Seborrheic Dermatitis

Del Prete S, Angeli A, Ghobril C, Hitce J, Clavaud C, Marat X, Supuran CT, Capasso C

Year: 2019

Comparison of the Anion Inhibition Profiles of the α-CA Isoforms (SpiCA1, SpiCA2 and SpiCA3) from the Scleractinian Coral Stylophora pistillata

Del Prete S, Bua S, Zoccola D, Alasmary F, Alothman Z, Alqahtani L, Techer N, Supuran C, Tambutté S, Capasso C

Year: 2019

Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling- protein-tag system (ASL tag )

Del Prete S, Merlo R, Valenti A, Mattossovich R, Rossi M, Carginale V, Supuran CT, Perugino G, Capasso C

Year: 2019

Cloning, purification, and characterization of a β-carbonic anhydrase from Malassezia restricta, an opportunistic pathogen involved in dandruff and seborrheic dermatitis

Del Prete S, Vullo D, Ghobril C, Hitce J, Clavaud C, Marat X, Capasso C, Supuran CT

Year: 2019

Exploring new structural features of the 4-[(3-methyl-4-aryl-2.3-dihydro-1.3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

Distinto S, Meleddu R, Ortuso F, Cottiglia F, Deplano S, Sequeira L, Melis C, Fois B, Angeli A, Capasso C, Angius R, Alcaro S, Supuran CT, Maccioni E

Year: 2019

Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives

Gitto R, De Luca L, Mancuso F, Del Prete S, Vullo D, Supuran CT, Capasso C

Year: 2019

Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates

Küçükbay H, Bugday N, Küçükbay FZ, Berrino E, Bartolucci G, Del Prete S, Capasso C, Supuran CT

Year: 2019

An AGT-based protein-tag system for the labelling and surface immobilization of enzymes on E. coli outer membrane

Merlo R, Del Prete S, Valenti A, Mattossovich R, Carginale V, Supuran CT, Capasso C, Perugino G

Year: 2019

Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors

Rogato A, Del Prete S, Nocentini A, Carginale V, Supuran CT, Capasso C

Year: 2019

Identification and characterization of the a-CA in the outer membrane vesicles produced by Helicobacter pylori

Ronci M, Del Prete S, Puca V, Carradori S, Carginale V, Muraro R, Mincione G, Aceto A, Sisto F, Supuran CT, Grande R, Capasso C

Year: 2019

Selenides bearing benzenesulfonamide show potent inhibition activity against carbonic anhydrases from pathogenic bacteria Vibrio cholerae and Burkholderia pseudomallei

Angeli A, Abbas G, del Prete S, Capasso C, Supuran CT

Year: 2018

The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids

Angeli A, Alasmary FA, Del Prete S, Osman SM, Alothman Z, Donald WA, Capasso C, Supuran CT

Year: 2018

The first activation studies of the η-carbonic anhydrase from the malaria parasite Plasmodium falciparum with amines and amino acids

Angeli A, Del Prete S, Alasmary FA, Alqahtani LS, Alothman Z, Donald WA, Capasso C, Supuran CT

Year: 2018

The γ-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae is potently activated by amines and amino acids

Angeli A, Del Prete S, Donald WA, Capasso C, Supuran CT

Year: 2018

Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids

Angeli A, Del Prete S, Osman SM, Alasmary FA, Alothman Z, Donald WA, Capasso C, Supuran CT

Year: 2018

Activation studies with amines and amino acids of the β-carbonic anhydrase encoded by the Rv3273 gene from the pathogenic bacterium Mycobacterium tuberculosis

Angeli A, Del Prete S, Osman SM, Alasmary FA, Alothman Z, Donald WA, Capasso C, Supuran CT

Year: 2018

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties

Angeli A, Pinteala M, Maier SS, Del Prete S, Capasso C, Simionescu BC, Supuran CT

Year: 2018

Inhibition of α-, β-, γ-, and δ-carbonic anhydrases from bacteria and diatoms with N′ -aryl- N -hydroxy-ureas

Berrino E, Bozdag M, Del Prete S, Alasmary FA, Alqahtani LS, Alothman Z, Capasso C, Supuran CT

Year: 2018

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes

Bua S, Berrino E, Del Prete S, Murthy VS, Vijayakumar V, Tamboli Y, Capasso C, Cerbai E, Mugelli A, Carta F, Supuran CT

Year: 2018

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii

Bua S, Bozdag M, Del Prete S, Carta F, Donald WA, Capasso C, Supuran CT

Year: 2018

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

De Luca L, Mancuso F, Ferro S, Buemi MR, Angeli A, Del Prete S, Capasso C, Supuran CT, Gitto R

Year: 2018

Protonography and anion inhibition profile of the α-carbonic anhydrase (CruCA4) identified in the Mediterranean red coral Corallium rubrum

Del Prete S, Vullo D, Caminiti-Segonds N, Zoccola D, Tambutté S, Supuran CT, Capasso C

Year: 2018

Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides

Meleddu R, Distinto S, Cottiglia F, Angius R, Gaspari M, Taverna D, Melis C, Angeli A, Bianco G, Deplano S, Fois B, Del Prete S, Capasso C, Alcaro S, Ortuso F, Yanez M, Supuran CT, Maccioni E

Year: 2018

Targeting tumor associated carbonic anhydrases IX and XII: highly isozyme selective coumarin and psoralen inhibitors

Melis C, Distinto S, Bianco G, Meleddu R, Cottiglia F, Fois B, Taverna D, Angius R, Alcaro S, Ortuso F, Gaspari M, Angeli A, Del Prete S, Capasso C, Supuran CT, Maccioni E

Year: 2018

Natural polyphenols selectively inhibit β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa: activity and modeling studies

Nocentini A, Bua S, Del Prete S, Heravi YE, Saboury AA, Karioti A, Bilia AR, Capasso C, Gratteri P, Supuran CT

Year: 2018

Characterization of technical grade carbonic anhydrase as biocatalyst for CO₂ capture in potassium carbonate solutions

Peirce S, Perfetto R, Russo ME, Capasso C, Rossi M, Salatino P, Marzocchella A

Year: 2018

Kinetic characterization of carbonic anhydrase immobilized on magnetic nanoparticles as biocatalyst for CO₂ capture

Peirce S, Russo M, Perfetto R, Capasso C, Rossi M, Fernandez-Lafuente R, Salatino P, Marzocchella A

Year: 2018

Enzymatic reactive CO₂ absorption: biocatalyst development and characterization

Peirce S, Russo ME, Perfetto R, Capasso C, Rossi M, Marzocchella A, Salatino P

Year: 2018

Immobilization of carbonic anhydrase for enhancement of CO₂ reactive absorption

Russo ME, Peirce S, Perfetto R, Capasso C, Rossi M, Marzocchella A, Salatino, P

Year: 2018

Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides

Stefanucci A, Angeli A, Dimmito MP, Luisi G, Del Prete S, Capasso C, Donald WA, Mollica A, Supuran CT

Year: 2018

Biomedical applications of prokaryotic carbonic anhydrases

Supuran CT, Capasso C

Year: 2018

Comparison of the amine/amino acid activation profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei

Vullo D, Del Prete S, Osman SM, Alasmary FA, Alothman Z, Donald WA, Capasso C, Supuran CT

Year: 2018

Supported ionic liquid membranes immobilized with carbonic anhydrases for CO2 transport at high temperatures

Abdelrahim MY, Martins CF, Neves L, Capasso C, Supuran CT, Coelhoso IM, Crespo JG, Barboiu M

Year: 2017

Mesenchymal stromal cells having inactivated RB1 survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapy

Alessio N, Capasso S, Di Bernardo G, Cappabianca S, Casale F, Calarco A, Cipollaro M, Peluso G, Galderisi U

Year: 2017

Misidentified human gene functions with mouse models: the case of the retinoblastoma gene family in senescence

Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, Peluso G, Giordano A, Galderisi U

Year: 2017

Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors

Angapelly S, Ramya PS, Angeli A, Del Prete S, Capasso C, Arifuddin M, Supuran CT

Year: 2017

Acyl selenoureido benzensulfonamides show potent inhibitory activity against carbonic anhydrases from the pathogenic bacterium Vibrio cholerae

Angeli A, Abbas G, Del Prete S, Carta F, Capasso C, Supuran CT

Year: 2017

Inhibition of Bacterial Carbonic Anhydrases as a Novel Approach to Escape Drug Resistance

Capasso C, Supuran C

Year: 2017

Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties

De Vita D, Angeli A, Pandolfi F, Bortolami M, Costi R, Di Santo R, Suffredini E, Ceruso M, Del Prete S, Capasso C, Scipione L, Supuran CT

Year: 2017

A one-step procedure for immobilising the thermostable carbonic anhydrase (SspCA) on the surface membrane of Escherichia coli

Del Prete S, Perfetto R, Rossi M, Alasmary FA, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2017

Comparison of the anion inhibition profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei

Del Prete S, Vullo D, di Fonzo P, Carginale V, Supuran CT, Capasso C

Year: 2017

Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis

Del Prete S, Vullo D, Di Fonzo P, Osman SM, Alothman Z, Donald WA, Supuran CT, Capasso C

Year: 2017

Anion inhibition profiles of the γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics

Del Prete S, Vullo D, Di Fonzo P, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2017

Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis

Del Prete S, Vullo D, Osman SM, Alothman Z, Donald WA, Winum JY, Supuran CT, Capasso C

Year: 2017

Sulfonamide inhibition profiles of the β-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia

Del Prete S, Vullo D, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2017

Kinetic properties and affinities for sulfonamide inhibitors of an α-carbonic anhydrase (CruCA4) involved in coral biomineralization in the Mediterranean red coral Corallium rubrum

Del Prete S, Vullo D, Zoccola D, Tambutté S, Capasso C, Supuran CT

Year: 2017

Activation Profile Analysis of CruCA4, an α-Carbonic Anhydrase Involved in Skeleton Formation of the Mediterranean Red Coral, Corallium rubrum

Del Prete S, Vullo D, Zoccola D, Tambutté S, Supuran C, Capasso C

Year: 2017

Inhibition of Malassezia globosa carbonic anhydrase with phenols

Entezari Heravi Y, Bua S, Nocentini A, Del Prete S, Saboury AA, Sereshti H, Capasso C, Gratteri P, Supuran CT

Year: 2017

Investigating the antiplasmodial activity of primary sulfonamide compounds identified in open source malaria data

Fisher GM, Bua S, Del Prete S, Arnold MS, Capasso C, Supuran CT, Andrews KT, Poulsen SA

Year: 2017

Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors

Kumar R, Bua S, Ram S, Del Prete S, Capasso C, Supuran CT, Sharma PK

Year: 2017

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

Melis C, Meleddu R, Angeli A, Distinto S, Bianco G, Capasso C, Cottiglia F, Angius R, Supuran CT, Maccioni E

Year: 2017

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study

Nocentini A, Cadoni R, del Prete S, Capasso C, Dumy P, Gratteri P, Supuran CT, Winum JY

Year: 2017

Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates

Nocentini A, Vullo D, Del Prete S, Osman SM, Alasmary FA, Alothman Z, Capasso C, Carta F, Gratteri P, Supuran CT

Year: 2017

Screening of enzyme immobilization techniques for carbonic anhydrase based biocatalyst

Peirce S, Russo ME, Perfetto R, Capasso C, Rossi M, Marzocchella A, Salatino P

Year: 2017

Cloning, expression and purification of the α-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis

Perfetto R, Del Prete S, Vullo D, Carginale V, Sansone G, Barone CM, Rossi M, Alasmary FA, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2017

Sequence Analysis, Kinetic Constants, and Anion Inhibition Profile of the Nacrein-Like Protein (CgiNAP2X1) from the Pacific Oyster Magallana gigas (Ex-Crassostrea gigas)

Perfetto R, Del Prete S, Vullo D, Sansone G, Barone C, Rossi M, Supuran C, Capasso C

Year: 2017

Biochemical characterization of the native α-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilus galloprovincialis

Perfetto R, Del Prete S, Vullo D, Sansone G, Barone C, Rossi M, Supuran CT, Capasso C

Year: 2017

Production and covalent immobilisation of the recombinant bacterial carbonic anhydrase (SspCA) onto magnetic nanoparticles

Perfetto R, Del Prete S, Vullo D, Sansone G, Barone CM, Rossi M, Supuran CT, Capasso C

Year: 2017

Carbonic Anhydrase from Porphyromonas gingivalis as a Drug Target

Supuran C, Capasso C

Year: 2017

An Overview of the Bacterial Carbonic Anhydrases

Supuran C, Capasso C

Year: 2017

Comparison of the Sulfonamide Inhibition Profiles of the β- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei

Vullo D, Del Prete S, Di Fonzo P, Carginale V, Donald W, Supuran C, Capasso C

Year: 2017

Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa

Vullo D, Del Prete S, Nocentini A, Osman SM, Alothman Z, Capasso C, Bozdag M, Carta F, Gratteri P, Supuran CT

Year: 2017

Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines

Vullo D, Del Prete S, Osman SM, Alothman Z, Capasso C, Donald WA, Supuran CT

Year: 2017

Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines

Abdel Gawad NM, Amin NH, Elsaadi MT, Mohamed FM, Angeli A, De Luca V, Capasso C, Supuran CT

Year: 2016

Discovery of new potential anti-infective compounds based on carbonic anhydrase inhibitors by rational target-focused repurposing approaches

Annunziato G, Angeli A, D’Alba F, Bruno A, Pieroni M, Vullo D, De Luca V, Capasso C, Supuran CT, Costantino G

Year: 2016

A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules

Borrelli A, Schiattarella A, Mancini R, Pica A, Pollio ML, Ruggiero MG, Bonelli P, De Luca V, Tuccillo FM, Capasso C, Gori E, Sanseverino M, Carpentieri A, Birolo L, Pucci P, Rommelaere J, Mancini A

Year: 2016

An overview of the carbonic anhydrases from two pathogens of the oral cavity: Streptococcus mutans and Porphyromonas gingivalis

Capasso C, Supuran C

Year: 2016

Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea

De Luca V, Vullo D, Del Prete S, Carginale V, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2016

Recombinant thermoactive phosphoenolpyruvate carboxylase (PEPC) from Thermosynechococcus elongatus and its coupling with mesophilic/thermophilic bacterial carbonic anhydrases (CAs) for the conversion of CO₂ to oxaloacetate

Del Prete S, De Luca V, Capasso C, Supuran CT, Carginale V

Year: 2016

Cloning, expression and purification of the complete domain of the η -carbonic anhydrase from Plasmodium falciparum

Del Prete S, De Luca V, De Simone G, Supuran CT, Capasso C

Year: 2016

Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae

Del Prete S, Vullo D, De Luca V, Carginale V, di Fonzo P, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2016

Anion inhibition profiles of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum

Del Prete S, Vullo D, De Luca V, Carginale V, di Fonzo P, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2016

Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae

Del Prete S, Vullo D, De Luca V, Carginale V, Ferraroni M, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2016

Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum

Del Prete S, Vullo D, De Luca V, Carginale V, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2016

Comparison of the sulfonamide inhibition profiles of the alpha-, beta- and gamma-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae

Del Prete S, Vullo D, De Luca V, Carginale V, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2016

A magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization

Ozensoy Guler O, Capasso C, Supuran CT

Year: 2016

New light on bacterial carbonic anhydrases phylogeny based on the analysis of signal peptide sequences

Supuran CT, Capasso C

Year: 2016

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea

Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Osman SM, Alothman Z, Capasso C, Supuran CT

Year: 2016

Carbonic anhydrase activators: activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids

Vullo D, Del Prete S, Capasso C, Supuran CT

Year: 2016

Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae

Vullo D, Del Prete S, De Luca V, Carginale V, Ferraroni M, Dedeoglu N, Osman SM, Alothman Z, Capasso C, Supuran CT

Year: 2016

Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-, [1.2,4]triazolo[3.4-b][1.3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1.3,4-thiadiazol-3(2H)-yl moieties

Alafeefy AM, Abdel-Aziz HA, Vullo D, Al-Tamimi AS, Awaad AS, Mohamed MA, Capasso C, Supuran CT

Year: 2015

Inhibition studies of quinazoline-sulfonamide derivatives against the γ-CA (PgiCA) from the pathogenic bacterium, Porphyromonas gingivalis

Alafeefy AM, Ceruso M, Al-Tamimi AS, Prete SD, Supuran CT, Capasso C

Year: 2015

Carbonic anhydrase protects fatty liver grafts against ischemic reperfusion damage

Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch-Puy E, Hotter G, Capasso C, T. Supuran C, Rosselló-Catafau J

Year: 2015

Acetazolamide protects steatotic liver grafts against cold ischemia reperfusion injury

Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch-Puy E, Serafin A, Capasso C, Supuran CT, Rossello-Catafau J

Year: 2015

Bacterial Carbonic Anhydrases as Drug Targets

Capasso C, Supuran CT

Year: 2015

Carbonic Anhydrases From Extremophiles and Their Biotechnological Applications

Capasso C, Supuran CT

Year: 2015

Bacterial, fungal and protozoan carbonic anhydrases as drug targets

Capasso C, Supuran CT

Year: 2015

An overview of the selectivity and efficiency of the bacterial carbonic anhydrase inhibitors

Capasso C, Supuran CT

Year: 2015

Poly(amidoamine) dendrimers show carbonic anhydrase inhibitory activity against α-, β-, γ- and η-class enzymes

Carta F, Osman SM, Vullo D, Alothman Z, Del Prete S, Capasso C, Supuran CT

Year: 2015

Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune

De Luca V, Del Prete S, Carginale V, Vullo D, Supuran CT, Capasso C

Year: 2015

Expression and characterization of a recombinant psychrophilic ?-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc

De Luca V, Del Prete S, Vullo D, Carginale V, Di Fonzo P, Osman SM, AlOthman Z, Supuran CT, Capasso C

Year: 2015

Expression and characterization of a recombinant psychrophilic γ-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc

De Luca V, Del Prete S, Vullo D, Carginale V, Di Fonzo P, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2015

Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis

De Luca V, Vullo D, Del Prete S, Carginale V, Scozzafava A, Osman SM, Alothman Z, Supuran CT, Capasso C

Year: 2015

The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families

De Simone G, Di Fiore A, Capasso C, Supuran CT

Year: 2015

Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense

De Simone G, Monti SM, Alterio V, Buonanno M, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C, Di Fiore A

Year: 2015

Cloning, characterization and anion inhibition study of a β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans

Dedeoglu N, De Luca V, Isik S, Yildirim H, Kockar F, Capasso C, Supuran CT

Year: 2015

Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans

Dedeoglu N, Deluca V, Isik S, Yildirim H, Kockar F, Capasso C, Supuran CT

Year: 2015

Protonography, a powerful tool for analyzing the activity and the oligomeric state of the γ-carbonic anhydrase identified in the genome of Porphyromonas gingivalis

Del Prete S, De Luca V, Iandolo E, Supuran CT, Capasso C

Year: 2015

Protonography, a technique applicable for the analysis of η-carbonic anhydrase activity

Del Prete S, De Luca V, Supuran CT, Capasso C

Year: 2015

A new procedure for the cloning, expression and purification of the ?-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target.

Del Prete S, De Luca V, Vullo D, Osman SM, AlOthman Z, Carginale V, Supuran CT Capasso C

Year: 2015

A new procedure for the cloning, expression and purification of the β-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target

Del Prete S, De Luca V, Vullo D, Osman SM, Alothman Z, Carginale V, Supuran CT, Capasso C

Year: 2015

Biochemical characterization of recombinant β-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis

Del Prete S, Vullo D, De Luca V, Alothman Z, Osman SM, Supuran CT, Capasso C

Year: 2015

Anion inhibition studies of the dandruff-producing fungus Malassezia globosa β-carbonic anhydrase MgCA

Del Prete S, Vullo D, Osman SM, Alothman Z, Capasso C, Supuran CT

Year: 2015

Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae

Ferraroni M, Del Prete S, Vullo D, Capasso C, Supuran CT

Year: 2015

The η-class carbonic anhydrases as drug targets for antimalarial agents

Supuran CT, Capasso C

Year: 2015

Acatalytic Carbonic Anhydrases (CAs VIII, X, XI)

Supuran CT, Capasso C

Year: 2015

Carbonic Anhydrase II as Target for Drug Design

Supuran CT, Capasso C, De Simone G

Year: 2015

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune

Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Capasso C, Supuran CT

Year: 2015

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis

Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Capasso C, Supuran CT

Year: 2015

Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum

Vullo D, Del Prete S, Fisher GM, Andrews KT, Poulsen SA, Capasso C, Supuran CT

Year: 2015

Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1.2.4]triazolo[3.4-b][1.3.4]thiadiazinyl- or 2-(cyanophenylmethylene)-1.3.4-thiadiazol-3(2H)-yl moieties

Alafeefy AM, Abdel-Aziz HA, Vullo D, Al-Tamimi Abdul-Malek S, Al-Jaber NA, Capasso C, Supuran CT

Year: 2014

Quinazoline-sulfonamides with potent inhibitory activity against the alpha-carbonic anhydrase from Vibrio cholerae

Alafeefy AM, Ceruso M, Al-Tamimi Abdul-Malek S, Del Prete S, Capasso C, Supuran CT

Year: 2014

Carbonic anhydrase inhibitors. Phenols incorporating 2-or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae beta-carbonic anhydrase

Bilginer S, Unluer E, Gul HI, Mete E, Isik S, Vullo D, Ozensoy-Guler O, Beyaztas S, Capasso C, Supuran CT

Year: 2014

An overview of the alpha-, beta- and gamma-carbonic anhydrases from Bacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?

Capasso C, Supuran CT

Year: 2014

An Overview of the Selectivity and Efficiency of the Bacterial Carbonic Anhydrase Inhibitors

Capasso C, Supuran CT

Year: 2014

Sulfa and trimethoprim-like drugs-antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors

Capasso C, Supuran CT

Year: 2014

Sulfonamides with Potent Inhibitory Action and Selectivity against the alpha-Carbonic Anhydrase from Vibrio cholerae

Ceruso M, Del Prete S, Alothman Z, Capasso C, Supuran CT

Year: 2014

Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis gamma-carbonic anhydrase

Ceruso M, Del Prete S, Alothman Z, Osman SM, Scozzafava A, Capasso C, Supuran CT

Year: 2014

A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes

De Luca V, Del Prete S, Carginale V, Vullo D, Supuran CT, Capasso C

Year: 2014

Protonography, a new technique for the analysis of carbonic anhydrase activity.

De Luca V, Del Prete S, Supuran CT, Capasso C

Year: 2014

Biochemical properties of a new alpha-carbonic anhydrase from the human pathogenic bacterium, Vibrio cholerae

Del Prete S, De Luca V, Scozzafava A, Carginale V, Supuran CT, Capasso C

Year: 2014

Biochemical characterization of the gamma-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA

Del Prete S, De Luca V, Vullo D, Scozzafava A, Carginale V, Supuran CT, Capasso C

Year: 2014

Biochemical characterization of recombinant beta-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis

Del Prete S, Vullo D, De Luca V, AlOthman Z, Osman SM, Supuran CT, Capasso C

Year: 2014

Biochemical characterization of the delta-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA

Del Prete S, Vullo D, De Luca V, Supuran CT, Capasso C

Year: 2014

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-The eta-carbonic anhydrases

Del Prete S, Vullo D, Fisher Gillian M, Andrews KT, Poulsen S-A, Capasso C, Supuran CT

Year: 2014

Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the beta-class (PgiCAb) versus the gamma-class (PgiCA) enzymes.

Del Prete S, Vullo D, Osman SM, Scozzafava A, AlOthman Z, Capasso C, Supuran CT

Year: 2014

Cloning, characterization and anion inhibition study of the delta-class carbonic anhydrase (TweCA) from the marine diatom Thalassiosira weissflogii

Del Prete S, Vullo D, Scozzafava A, Capasso C, Supuran CT

Year: 2014

Shading the TRF2 recruiting function: a new horizon in drug development

Maro SD, Zizza P, Salvati E, Luca VD, Capasso C, Fotticchia I, Pagano B, Marinelli L, Gilson E, Novellino E, Cosconati S, Biroccio A

Year: 2014

Biomimetic CO₂ capture using a highly thermostable bacterial α-carbonic anhydrase immobilized on a polyurethane foam

Migliardini F, De Luca V, Carginale V, Rossi M, Corbo P, Supuran CT, Capasso C

Year: 2014

Sulfonamide inhibition studies of two beta-carbonic anhydrases from the bacterial pathogen Legionella pneumophila

Nishimori I, Vullo D, Minakuchi T, Scozzafava A, Capasso C, Supuran CT

Year: 2014

Anion inhibition studies of two new beta-carbonic anhydrases from the bacterial pathogen Legionella pneumophila

Nishimori I, Vullo D, Minakuchi T, Scozzafava A, Osman SM, Alothman Z, Capasso C, Supuran CT

Year: 2014

Effect of a recombinant manganese superoxide dismutase on prevention of contrast-induced acute kidney injury

Pisani A, Sabbatini M, Riccio E, Rossano R, Andreucci M, Capasso C, De Luca V, Carginale V, Bizzarri M, Borrelli A, Schiattarella A, Santangelo M, Mancini A

Year: 2014

Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease

Rodrigues GC, Feijo DF, Bozza MT, Pan P, Vullo D, Parkkila S, Supuran CT, Capasso C, Aguiar AP, Vermelho AB

Year: 2014

Sulfonamide inhibition studies of the delta-carbonic anhydrase from the diatom Thalassiosira weissflogii

Vullo D, Del Prete S, Osman SM, De Luca V, Scozzafava A, Alothman Z, Supuran CT, Capasso C

Year: 2014

Sulfonamide inhibition studies of the gamma-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis

Vullo D, Del Prete S, Osman SM, De Luca V, Scozzafava A, Alothman Z, Supuran CT, Capasso C

Year: 2014

Anion inhibition study of the beta-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis

Vullo D, Del Prete S, Osman SM, Scozzafava A, Alothman Z, Supuran CT, Capasso C

Year: 2014

Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2

Vullo D, Flemetakis E, Scozzafava A, Capasso C, Supuran CT

Year: 2014

Anion inhibition study of the beta-carbonic anhydrase (CahB1) from the cyanobacterium Coleofasciculus chthonoplastes (ex-Microcoleus chthonoplastes)

Vullo D, Kupriyanova EV, Scozzafava A, Capasso C, Supuran CT

Year: 2014

Biochemical characterization of the δ-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA

Del Prete S, Vullo D, De Luca V, Supuran CT, Capasso C

Year: 2013

A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi

Güzel-Akdemir Ö, Akdemir A, Pan P, Vermelho AB, Parkkila S, Scozzafava A, Capasso C, Supuran CT

Year: 2013

Toxicity, accumulation, and removal of heavy metals by three aquatic macrophytes

Basile A, Sorbo S, Conte B, Cobianchi RC, Trinchella F, Capasso C, Carginale V

Year: 2012