Michele Bellucci
Ruolo: Primo Ricercatore
Comparto: Ricercatori e Tecnologi
Sede: Perugia
Tel: (39) 075-5014815
E-mail: michele.bellucci[at]cnr.it
Ruolo
Primo Ricercatore presso IBBR/CNR
ORCID ID: http://orcid.org/0000-0001-7476-9603
PUBLONS ID: publons.com/a/1264874/
Esperienze precedenti
1994: Istituto Sperimentale per le Colture Foraggere di Lodi (Milano), CRA. Borsa di studio.
1995 - 1999: Istituto di Ricerche sul Miglioramento Genetico delle Piante Foraggere (IRMGPF), Perugia, CNR. Borse di studio.
1999 - 2006: Tecnico presso l’Istituto di Genetica Vegetale (IGV), U.O.S di Perugia, CNR.
2006 - 2020 Ricercatore presso l’ IGV (divenuto IBBR nel 2013), U.O.S di Perugia, CNR.
Dal 2020 Primo Ricercatore presso IBBR, U.O.S di Perugia, CNR.
Studi
Laurea: Università di Perugia, 1992
Dottorato: Università di Perugia, 2003
- Biotecnologia dei plastidi
Trasformazione del tabacco mediante ingegneria genetica applicata ai plastidi per accumulare proteine ricombinanti nel cloroplasto. L’esperienza accumulata con i protocolli di trasformazione del tabacco ci ha consentito poi di riuscire a trasformare anche il DNA dei plastidi di barbabietola da zucchero. Inoltre, abbiamo portato avanti studi sulla stabilità proteica delle proteine eterologhe espresse nel cloroplasto.
- Colture vegetali per uso alternativo
Produzione di molecole biofarmaceutiche e bioplastica in pianta: espressione in pianta (tabacco) di enzimi umani, in collaborazione con l’Università di Perugia. Studi di genetica sul luppolo (Humulus lupulus L.).
- Via di secrezione
Investigazione su diversi aspetti legati al traffico delle proteine di secrezione verso il reticolo endoplasmatico (RE) o il vacuolo. Abbiamo dimostrato l’esistenza di una via per il controllo di qualità delle proteine nel RE, che le degrada indirizzandole al vacuolo, così come la presenza di nuovi segnali e vie per il rilascio di proteine al vacuolo (secrezione non-convenzionale di proteine).
Contatti
Tel: + 39 075 5014815
E-mail: michele.bellucci@cnr.it
Indirizzo
Michele Bellucci
Istituto di Bioscienze e BioRisorse (IBBR), CNR,
via Madonna Alta 130,
06128 Perugia, Italia
Pubblicazioni
http://scholar.google.it/citations?user=tDBZuFUAAAAJ&hl=it&oi=ao
Lista Pubblicazioni
(lista completa disponibile su CNR People)
A biotechnological approach for the production of new protein bioplastics
De Marchis F, Vanzolini T, Maricchiolo E, Bellucci M, Menotta M, Di Mambro T, Aluigi A, Zattoni A, Roda B, Marassi V, Crinelli R, Pompa A
Anno: 2024
ORIGIN OF RECOGNITION COMPLEX 3 controls the development of maternal excess endosperm in the Paspalum simplex agamic complex ( Poaceae )
Bellucci M, Caceres ME, Paolocci F, Vega JM, Ortiz JP, Ceccarelli M, De Marchis F, Pupilli F
Anno: 2023
Genetic transformation of plant cells as a possible strategy for the production of bioactive compounds or biopolymers
Maricchiolo E, Bellucci M, De Marchis F, Fraternale D, Paolocci F, Zattoni A, Roda B, Marassi V, Pompa A
Anno: 2022
Unconventional Pathways of Protein Secretion: Mammals vs. Plants
Maricchiolo E, Panfili E, Pompa A, De Marchis F, Bellucci M, Pallotta MT
Anno: 2022
Human Indoleamine 2.3-dioxygenase 1 (IDO1) Expressed in Plant Cells Induces Kynurenine Production
Bellucci M, Pompa A, De Marcos Lousa C, Panfili E, Orecchini E, Maricchiolo E, Fraternale D, Orabona C, De Marchis F, Pallotta MT
Anno: 2021
Plastid transformation in Sugar Beet: an important industrial crop
De Marchis F, Bellucci M
Anno: 2021
Perspectives on protein biopolymers: miniaturized flow field-flow fractionation-assisted characterization of a single-cysteine mutated phaseolin expressed in transplastomic tobacco plants
Marassi V, De Marchis F, Roda B, Bellucci M, Capecchi A, Reschiglian P, Pompa A, Zattoni A
Anno: 2021
ERAD-mediated maturation of the regulatory protein of plant meristematic cells CLAVATA 3 emerged during evolution from algae to higher plants
Maricchiolo E, Marchis FD, Bellucci M, Cignotti A, Palma F, Carnaroli R, Fraternale D, Perozeni F, Pivato M, Pompa MBA
Anno: 2021
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1
Iacono A, Pompa A, De Marchis F, Panfili E, Greco FA, Coletti A, Orabona C, Volpi C, Belladonna ML, Mondanelli G, Albini E, Vacca C, Gargaro M, Fallarino F, Bianchi R, De Marcos Lousa C, Mazza EM, Bicciato S, Proietti E, Milano F, Martelli MP, Iamandii IM, Graupera Garcia-Amila M, Llena Sopena J, Hawkins P, Suire S, Okkenhaug K, Stark A, Grassi F, Bellucci M, Puccetti P, Santambrogio L, Macchiarulo A, Grohmann U, Pallotta MT
Anno: 2020
High genetic and chemical diversity of wild hop populations from Central Italy with signals of a genetic structure influenced by both sexual and asexual reproduction
Riccioni C, Belfiori B, Sileoni V, Marconi O, Perretti G, Bellucci M, Rubini A
Anno: 2020
Transfer of a mutant plant glutamate 1-semialdehyde aminotransferase gene from the nuclear to the plastid genome confers gabaculine resistance in tobacco
Bellucci M, De Marchis F, Pompa A, Micheli M, Gardi T, Rosellini D
Anno: 2019
Synthesis, purification and analysis of new plant biopolymers
De Marchis F, Bellucci M, Aluigi A, Zattoni A, Roda B, Marassi V, Morosinotto T, Pompa A
Anno: 2019
Unconventional protein secretion in plant cells: three cases study
De Marchis F, Bellucci M, Pallotta MT, Iacono A, Grohmann U, Pompa A
Anno: 2019
Host-endosymbiont co-evolution shaped chloroplast translational regulation
De Marchis F, Pompa A, Ballottari M, Bellucci M
Anno: 2019
Ovule gene expression analysis in sexual and aposporous apomictic Hypericum perforatum L. (Hypericaceae) accessions
Galla G, Basso A, Grisan S, Bellucci M, Pupilli F, Barcaccia G
Anno: 2019
A portion of the apomixis locus of Paspalum simplex is microsyntenic with an unstable chromosome segment highly conserved among Poaceae
Galla G, Siena LA, Ortiz JP, Baumlein H, Barcaccia G, Pessino SC, Bellucci M, Pupilli F
Anno: 2019
Genetic characterisation and agronomic and nutritional value of bitter vetch (Vicia ervilia), an under-utilised species suitable for low-input farming systems
Russi L, Acuti G, Trabalza-Marinucci M, Porta R, Rubini A, Damiani F, Cristiani S, Dal Bosco A, Martuscelli G, Bellucci M, Pupilli F
Anno: 2019
Plastid Proteostasis: Relevance of Transcription, Translation, and Post-translational Modifications
Alagna F, Bellucci M, Leister D, Pompa A
Anno: 2018
The vesicle trafficking regulator PN_SCD1 is demethylated and overexpressed in florets of apomictic Paspalum notatum genotypes
Bocchini M, Galla G, Pupilli F, Bellucci M, Barcaccia G, Ortiz JP, Pessino SC, Albertini E
Anno: 2018
A single cystein-enriched phaseolin expressed in transplastomic tobacco plants accumulates as a biopolymer
Capecchi A, De Marchis F, Bellucci M, Fallarino F, Zattoni A, Marassi V, Roda B, Pompa A
Anno: 2018
Expression of CLAVATA3 fusions indicates rapid intracellular processing and a role of ERAD
De Marchis F, Colanero S, Klein EM, Mainieri D, Prota VM, Bellucci M, Pagliuca G, Zironi E, Gazzotti T, Vitale A, Pompa A
Anno: 2018
Erratum to “Expression of CLAVATA3 fusions indicates rapid intracellular processing and a role of ERAD” [Plant Sci. 271 (2018) 67-80]
De Marchis F, Colanero S, Klein EM, Mainieri D, Prota VM, Bellucci M, Pagliuca G, Zironi E, Gazzotti T, Vitale A, Pompa A
Anno: 2018
Relationship between functions and intracellular localization of the immune checkpoint target indoleamine 2.3-dioxygenase 1
Iacono A, Pompa A, De Marchis F, Bellucci M, Grassi F, Grohmann U, Pallotta MT
Anno: 2018
Structure, target-specificity and expression of PN_LNC_N13, a long non-coding RNA differentially expressed in apomictic and sexual Paspalum notatum
Ochogavía A, Galla G, Seijo JG, González AM, Bellucci M, Pupilli F, Barcaccia G, Albertini E, Pessino S
Anno: 2018
Characterization of a single cystein-enriched phaseolin expressed in transplastomic tobacco plants
Zattoni A, Capecchi A, De Marchis F, Bellucci M, Fallarino F, Marassi V, Roda B, Pompa A
Anno: 2018
Editorial: Plastid Proteostasis: Relevance of Transcription, Translation, and Post-translational Modifications
Alagna F, Bellucci M, Leister D, Pompa A
Anno: 2017
The endoplasmic reticulum is a hub to sort proteins toward unconventional traffic pathways and endosymbiotic organelles
Bellucci M, De Marchis F, Pompa A
Anno: 2017
Expression of the plant GSA gene from the plastid genome
Bellucci M, De Marchis F, Pompa A, Micheli M, Veronesi F, Rosellini D
Anno: 2017
Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology
Pompa A, De Marchis F, Pallotta MT, Benitez-Alfonso Y, Jones A, Schipper K, Moreau K, Zárský V, Di Sansebastiano GP, Bellucci M
Anno: 2017
Identification and characterization of wild hop germplasm in Umbria region
Riccioni C, Belfiori B, Perretti G, Rubini A, Bellucci M
Anno: 2017
Expression of human FVIII coagulation factor in plants
Scattini G, De Marchis F, Bellucci M, Matino D, Fallarino F, Pompa A
Anno: 2017
Phaseolin expression in tobacco chloroplast reveals an autoregulatory mechanism in heterologous protein translation
De Marchis F, Bellucci M, Pompa A
Anno: 2016
Chemical secretory pathway modulation in plant protoplasts
De Marchis F, Pompa A, Bellucci M
Anno: 2016
Overexpression of the olive acyl carrier protein gene (OeACP1) produces alterations in fatty acid composition of tobacco leaves
De Marchis F, Valeri MC, Pompa A, Bouveret E, Alagna F, Grisan S, Stanzione V, Mariotti R, Cultrera N, Baldoni L, Bellucci M
Anno: 2016
Alternative use of tobacco as a sustainable crop for seed oil, biofuel, and biomass
Grisan S, Polizzotto R, Raiola P, Cristiani S, Ventura F, di Lucia F, Zuin M, Tommasini S, Morbidelli R, Damiani F, Pupilli F, Bellucci M
Anno: 2016
A mutant Synechococcus gene encoding glutamate 1-semialdehyde aminotransferase confers gabaculine resistance when expressed in tobacco plastids
Bellucci M, De Marchis F, Ferradini N, Pompa A, Veronesi F, Rosellini D
Anno: 2015
Phaseolin expression in tobacco chloroplast reveals an autoregulatory mechanism in heterologous protein translation
De Marchis F, Bellucci M, Pompa A
Anno: 2015
Increased oleic acid content in tobacco leaves due to the expression of an olive acyl carrier protein
De Marchis F, Valeri MC, Pompa A, Bouveret E, Alagna F, Grisan S, Stanzione V, Mariotti R, Cultrera N, Baldoni L, Bellucci M
Anno: 2015
An autoregulatory mechanism modulates translation of heterologous proteins in tobacco chloroplast
Pompa A, Bellucci M, De Marchis F
Anno: 2015
Isolation and molecular characterization of three acyl carrier protein genes in olive (Olea europaea L.)
Cultrera NGM, Alagna F, Mariotti R, De Marchis F, Pompa A, Bellucci M, Baldoni L
Anno: 2014
Plastid Transformation in Sugar Beet: Beta vulgaris
De Marchis F, Bellucci M
Anno: 2014
Obtainment of fertile and genetically stable transplastomic sugar beet plants over three generations
De Marchis F, Pompa A, Bellucci M
Anno: 2014
Traffic of Human α-Mannosidase in Plant Cells Suggests the Presence of a New Endoplasmic Reticulum-to-Vacuole Pathway without Involving the Golgi Complex
De Marchis F, Bellucci M, Pompa A
Anno: 2013
Unconventional pathways of secretory plant proteins from the endoplasmic reticulum to the vacuole bypassing the Golgi complex
De Marchis F, Bellucci M, Pompa A
Anno: 2013
Overexpression of an olive acyl carrier protein (ACP) in tobacco tissuues.
De Marchis F, Pompa A, Cultrera N, Mariotti R, Alagna F, Baldoni L, Bellucci M
Anno: 2013
The chloroplasts as platform for recombinant proteins production
Scotti N, Bellucci M, Cardi T
Anno: 2013
The chloroplasts as platform for recombinant proteins production
Scotti N, Bellucci M, Cardi T
Anno: 2013
Plastid proteostasis and heterologous protein accumulation in transplastomic plants
De Marchis F, Pompa A, Bellucci M
Anno: 2012
Il debutto della zeolina
Vitale A, Bellucci M
Anno: 2012
Production of human lysosomal alpha-mannosidase in transgenic tobacco plants
Beccari T, Balducci C, Pompa A, Stensland HM, Guaragno M, Pagliardini V, Menghini AR, Persichetti E, Bellucci M
Anno: 2011
Human a-mannosidase produced in transgenic tobacco plants is processed in human alpha-mannosidosis cell lines
De Marchis F, Balducci C, Pompa A, Hilde R, Stensland MF, Guaragno M, Pagiotti R, Menghini AR, Persichetti E, Beccari T, Bellucci M
Anno: 2011
A plant secretory signal peptide targets plastome-encoded recombinant proteins to the thylakoid
De Marchis F, Pompa A, Mannucci R, Morosinotto T, Bellucci M
Anno: 2011
Enzyme Replacement Therapy: Production of Human ?-Mannosidase in Transgenic Tobacco Plants
De Marchis Francesca, Balducci Chiara, Pagiotti Rita, Arcioni Sergio, Beccari Tommaso, Bellucci Michele
Anno: 2010
An engineered C-terminal disulfide bond can partially replace the phaseolin vacuolar sorting signal
Pompa A, De Marchis F, Vitale A, Arcioni S, Bellucci M
Anno: 2010
Endoplasmic reticulum signal peptide enhances folding of a chimeric protein when expressed in chloroplast
Pompa Andrea, De Marchis Francesca, Mannucci Roberta, Bellucci Michele
Anno: 2010
Genetic transformation of the sugar beet plastome
De Marchis F, Wang Y, Stevanato P, Arcioni S, Bellucci M
Anno: 2009
Plant-based strategies aimed at expressing HIV antigens and neutralizing antibodies at high levels. Nef as a case study
Marusic C, Vitale A, Pedrazzini E, Donini M, Frigerio L, Bock R, Dix PJ, McCabe MS, Bellucci M, Benvenuto E
Anno: 2009
Agrobacterium mediated genetic transformation of alfalfa
Bellucci M, De Marchis F, Arcioni S
Anno: 2008
The human immunodeficiency virus antigen Nef forms protein bodies in leaves of transgenic tobacco when fused to zeolin
De Virgilio M, De Marchis F, Bellucci M, Mainieri D, Rossi M, Benvenuto E, Arcioni S, Vitale A
Anno: 2008
Protein domains involved in assembly in the endoplasmic reticulum promote vacuolar delivery when fused to secretory GFP, indicating a protein quality control pathway for degradation in the plant vacuole
Foresti O, De Marchis F, de Virgilio M, Klein EM, Arcioni S, Bellucci M, Vitale A
Anno: 2008
Zeolin is a recombinant storage protein that can be used to produce value-added proteins in alfalfa (Medicago sativa L.)
Bellucci M, De Marchis F, Arcioni S
Anno: 2007
Zeolin is a recombinant storage protein with different solubility and stability properties according to its localization in the endoplasmic reticulum or in the chloroplast
Bellucci M, De Marchis F, Nicoletti I, Arcioni S
Anno: 2007
Cytoplasm and chloroplasts are not suitable subcellular locations for ß-zein accumulation in transgenic plants
Bellucci M, De Marchis F, Mannucci R, Bock R, Arcioni S
Anno: 2005
Transformation of Lotus corniculatus plants with Escherichia coli asparagines synthetase A: effect on nitrogen assimilation and plant development
Bellucci M, Ederli L, De Marchis F, Pasqualini S, Arcioni S
Anno: 2004
Zeolin, a new recombinant storage protein constructed using maize à‚Æ’×-zein and bean phaseolin
Mainieri D, Rossi M, Archinti M, Bellucci M, De Marchis F, Vavassori S, Pompa A, Arcioni S, Vitale A
Anno: 2004
Cytomixis in Pollen Mother Cells of Medicago sativa L
Bellucci M, Roscini C, Mariani A
Anno: 2003
Jellyfish green fluorescent protein as a useful reporter in Medicago sativa L. for transient expression and stable transformation
Bellucci Michele, De Marchis Francesca, Mannucci Roberta, Arcioni Sergio
Anno: 2003
Analisi della diffusione ambientale di polline transgenico di leguminose foraggere
De Marchis F, Bellucci M, Arcioni S
Anno: 2003
Measuring gene flow from two birdsfoot trefoil (Lotus corniculatus) field trials using transgenes as tracer markers
De Marchis Francesca, Bellucci Michele, Arcioni Sergio
Anno: 2003
La biotecnologia e il miglioramento genetico delle piante foraggere
Bellucci M, Arcioni S
Anno: 2002
Correct balance of the protein content in food and fodder crops through genetic engineering
Bellucci M, Arcioni S
Anno: 2002
Plant DNA methylation and gene expression
Bellucci M, Paolocci F, Damiani F, Arcioni S
Anno: 2002
Zein accumulation in forage species (Lotus corniculatus and Medicago sativa) and coexpression of gamma-zein:KDEL and beta-zein:KDEL polypeptides in tobacco leaf
Bellucci Michele, Alpini Angelica, Arcioni Sergio
Anno: 2002
The synthesis of condensed tannin in Lotus corniculatus: production and characterisation of polymorphic isogenic lines
Turchetti V, Tosti N, Ragano Caracciolo M, Bellucci M, Paolocci F, Damiani F
Anno: 2002
Metabolic regulation and gene expression of root phosphoenolpyruvate carboxylase by different nitrogen sources
Pasqualini S, Ederli L, Piccioni C, Batini P, Bellucci M, Arcioni S, Antonielli M
Anno: 2001
Expression of maize gamma-zein and beta-zein genes in transgenic Nicotiana tabacum and Lotus corniculatus
Bellucci M, Alpini A, Arcioni S
Anno: 2000
Accumulation of maize γ-zein and γ-zein: KDEL to high levels in tobacco leaves and differential increase of BiP synthesis in transformants
Bellucci M, Alpini A, Paolocci F, Cong L, Arcioni S
Anno: 2000
Transcription of a maize cDNA in Lotus corniculatus is regulated by T-DNA methylation and transgene copy number
Bellucci M, Alpini A, Paolocci F, Damiani F, Arcioni S
Anno: 1999
Variation for polyphenol oxidase activity in stems of Medicago species
Bellucci M, Pupilli F, Arcioni S
Anno: 1999
Differential expression of a gamma-zein gene in Medicago sativa, Lotus corniculatus and Nicotiana tabacum
Bellucci Michele, Lazzari Barbara, Viotti Angelo, Arcioni Sergio
Anno: 1997
Inhibition of Proteolitic Enzymes from Pseudomonas fluorescens ATTC 948 and Angiotensin I-Converting Enzyme by Peptides from Zein, Hordein and Gluten Hydrolizates
Gobbetti M, Smacchi E, Corsetti A, Bellucci M
Anno: 1997
Genetic control of somatic embryogenesis in alfalfa (Medicago sativa L. cv. Adriana)
Crea F, Bellucci M, Damiani F, Arcioni S
Anno: 1995
