Marta Gogliettino

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• Education

2014 PhD in Applied Biology at University of Naples “Federico II”, Italy.
2006 Approval to the profession of Chemist.
2005 Approval to the profession of Pharmacist.
2005 Degree in Pharmaceutical Chemistry and Technology achieved at the University of Naples “Federico II”, final mark: 110/110.

• Employment and experience

2006 Research training at Institute of Protein Biochemistry (IBP), National Council of
Research (CNR), Naples.

2006-2011: Fellow at IBP, CNR, Naples.

2011-2014: Research fellow at IBP, CNR, Naples.

2015: Researcher at Institute of Biosciences and Bioresources (IBBR), CNR, Naples

• Teaching

Since 2007, Dr. Gogliettino has assisted in the preparation of the thesis many students in biology, chemistry and biotechnology. She has given several seminars.

• Brief description of research activities

Dr. Marta Gogliettino has achieved her master degree in Pharmaceutical Chemistry and Technology at the University of Naples and she became PhD in Applied Biology at University of Naples “Federico II” in 2014. Since 2015 she is researcher at the National Research Council (CNR). Her scientific and research activity has been focused on the study of the structure/function relationship of proteins from different sources. After spending many years at the CNR, she has acquired considerable expertise in the field of biochemistry and molecular biology with particular reference to the study of enzymes from prokaryotic and eukaryotic organisms. Specifically, the research activity has allowed her to get a consolidated know-how concerning the protein purification procedures as well as kinetic, chemical-physical, and structural characterization of enzymes. Moreover, Dr. Gogliettino has contributed to 13 research articles published on peer-reviewed journals. Moreover, her research activities produced about 18 contributions to conference proceedings and she has participated in national and international congresses.
The main lines of her research are: A. Study of the activity of molecules able to regulate the function of target enzymes involved in protein turnover and in the antioxidant defense mechanisms in vitro and in vivo models; B. Study of proteases from hyperthermophilic and eukaryotic organisms; C. Identification of protease inhibitors; D. Study of ‘Oligopeptide binding proteins’ belonging to ABC (ATP-binding cassette) transporters in hyperthermophilic microorganisms

• Peer-reviewed Publications

A. Riccio, M. Gogliettino, M. Balestrieri, E. Cocca, A. Facchiano, M. Rossi, S. Palumbo, G. Monti, G. Palmieri. A new APEH cluster with antioxidant functions in the Antarctic hemoglobinless icefish Chionodraco hamatus. PLoS One (2015); 10(5):e0125594.

P. Bergamo, G. Palmieri, E. Cocca, I. Ferrandino, M. Gogliettino, A. Monaco, G. Mazzarella, F. Maurano, C. David and M. Rossi. Adaptive response activated by dietary cis9, trans11 Conjugated Linoleic Acid prevents distinct signs of gliadin-induced enteropathy in mice. EJN (2015) DOI 10.1007/s00394-015-0893-2.

M. Gogliettino, A. Riccio, E. Cocca, M. Rossi, G. Palmieri and M. Balestrieri. A New Pepstatin-Insensitive Thermopsin-Like Protease Overproduced in Peptide-Rich Cultures of Sulfolobus solfataricus. IJMS (2014); 15: 3204-3219.

P. Bergamo, E. Cocca, R. Palumbo, M. Gogliettino, M. Rossi, G. Palmieri. RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10,c12-Conjugated Linoleic Acid isomer on melanoma cell lines. PLoS One (2013); 8: e80900.

Gogliettino M, Riccio A, Balestrieri M, Cocca E, Facchiano A, D’Arco TM, Tesoro C, Rossi M, Palmieri G. A novel class of bifunctional acylpeptide hydrolases--potential role in the antioxidant defense systems of the Antarctic fish Trematomus bernacchii. FEBS J. (2014); 281(1):401-15.

M. Gogliettino, M. Balestrieri, E. Cocca, S. Mucerino, M. Rossi, M. Petrillo, E. Mazzella, G. Palmieri. Identification and characterisation of a novel acylpeptide hydrolase from Sulfolobus solfataricus: structural and functional insights. PLoS One (2012); 7(5): e37921.

A. Sandomenico, A. Russo, G. Palmieri, P. Bergamo, M. Gogliettino, L. Falcigno, M. Ruvo. Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation. J Med Chem (2012), 8;55(5): 2102-11.

P. Bergamo, M. Gogliettino, G.Palmieri, E. Cocca, F. Maurano, R. Stefanile, M. Balestrieri, G. Mazzarella, C. David,¶ and M. Rossi. Conjugated Linoleic Acid protects against gliadin-induced depletion of intestinal defenses. Mol Nutr Food Res (2011), 55: S248-S256.

G. Palmieri, P. Bergamo, A. Luini, M. Ruvo, M. Gogliettino, E. Langella, M. Saviano, R. Hegde, A. Sandomenico, and M. Rossi. Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation. Plos One (2011), 6(10):e25888.

M. Balestrieri, M. Gogliettino, I Fiume, G. Catara, G. Marino, M. Rossi and G. Palmieri. Structural and functional insights into Aeropyrum pernix OppA, a member of a novel archaeal OppA subfamily. J Bac (2011) 193: 620 - 630.

G. Palmieri, E. Langella, M. Gogliettino, M. Saviano, G. Pocsfalvi and M. Rossi. A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): a study of the acyl peptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus. Mol BioSyst (2010), 6:2498-2507.

M. Gogliettino, M. Balestrieri, G. Pocsfalvi, I. Fiume, L. Natale, M. Rossi, and G. Palmieri. A highly selective oligopeptide binding protein from the Archaeon Sulfolobus solfataricus. J Bac (2010) 192 (12): 3123-3131.

G. Palmieri, G. Catara, M. Saviano, E. Langella, M. Gogliettino, and M. Rossi. First archaeal PEBP-serine protease inhibitor from Sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop. J Proteome Res (2009) 8(1): 327-334.

Selected Publications

(full list available at CNR People)

An Active Peptide-Based Packaging System to Improve the Freshness and Safety of Fish Products: A Case Study

Ambrosio RL, Gogliettino M, Agrillo B, Proroga YT, Balestrieri M, Gratino L, Cristiano D, Palmieri G, Anastasio A

Year: 2022

Recombinant Expression of Archaeal Superoxide Dismutases in Plant Cell Cultures: A Sustainable Solution with Potential Application in the Food Industry

Gogliettino M, Arciello S, Cillo F, Carluccio AV, Palmieri G, Apone F, Ambrosio RL, Anastasio A, Gratino L, Carola A, Cocca E

Year: 2022

Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme

Sandomenico A, Gogliettino M, Iaccarino E, Fusco C, Caporale A, Ruvo M, Palmieri G, Cocca E

Year: 2022

Key Physicochemical Determinants in the Antimicrobial Peptide RiLK1 Promote Amphipathic Structures

Falcigno L, D’auria G, Palmieri G, Gogliettino M, Agrillo B, Tatè R, Dardano P, Nicolais L, Balestrieri M

Year: 2021

A safe and multitasking antimicrobial decapeptide: the road from de novo design to structural and functional characterization

Agrillo B, Proroga YT, Gogliettino M, Balestrieri M, Tatè R, Nicolais L, Palmieri G

Year: 2020

The bactericidal activity of protein extracts from Loranthus europaeus Berries: a natural resource of bioactive compounds

Ambrosio RL, Gratino L, Mirino S, Cocca E, Pollio A, Anastasio A, Palmieri G, Balestrieri M, Genovese A, Gogliettino M

Year: 2020

Rapid biofilm eradication of the antimicrobial peptide 1018-K6 against Staphylococcus aureus: a new potential tool to fight bacterial biofilms

Colagiorgi A, Festa R, Di Ciccio PA, Gogliettino M, Balestrieri M, Palmieri G, Anastasio A, Ianieri A

Year: 2020

Extending the shelf-life of meat and dairy products via PET-modified packaging activated with the antimicrobial peptide MTP1

Gogliettino M, Balestrieri M, Ambrosio RL, Anastasio A, Smaldone G, Proroga YT, Moretta R, Rea I, De Stefano L, Agrillo B, Palmieri G

Year: 2020

New antimicrobial devices to prevent waterborne diseases

Palmieri G, Cammarano A, Agrillo B, Proroga YT, Gogliettino M, Balestrieri M, De Stefano L, Battisti M, De Martino S, Mercurio ME, Cummaro A, Nicolais L

Year: 2020

Functionalized polymeric materials with bio-derived antimicrobial peptides for “active” packaging

Agrillo B, Balestrieri M, Gogliettino M, Palmieri G, Moretta R, Proroga Y, Rea I, Cornacchia A, Capuano F, Smaldone G, De Stefano L

Year: 2019

An alternative biocontrol agent of soil-borne phytopathogens: A new antifungal compound produced by a plant growth promoting bacterium isolated from North Algeria

Agrillo B, Mirino S, Tatè R, Gratino L, Gogliettino M, Cocca E, Tabli N, Nabti E, Palmieri G

Year: 2019

The extraordinary resistance to UV radiations of a manganese superoxide dismutase of Deinococcus radiodurans offers promising potentialities in skin care applications

Palmieri G, Arciello S, Bimonte M, Carola A, Tito A, Gogliettino M, Cocca E, Fusco C, Balestrieri M, Colucci MG, Apone F

Year: 2019

Small synthetic peptides bioconjugated to hybrid gold nanoparticles destroy potentially deadly bacteria at submicromolar concentrations

Palmieri G, Tatè R, Gogliettino M, Balestrieri M, Rea I, Terracciano M, Proroga YT, Capuano F, Anastasio A, De Stefano L

Year: 2018

Unusual Antioxidant Properties of 26S Proteasome Isolated from Cold-Adapted Organisms

Gogliettino M, Cocca E, Fusco C, Agrillo B, Riccio A, Balestrieri M, Facchiano A, Pepe A, Palmieri G

Year: 2017

Isolation and characterization from solar salterns of North Algeria of a haloarchaeon producing a new halocin

Mazguene S, Rossi M, Gogliettino M, Palmieri G, Cocca E, Mirino S, Imadalou-Idres N, Benallaoua S

Year: 2017

Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer’s Disease: A Sign of Defective Proteostasis?

Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A

Year: 2017

Plant growth promoting and inducible antifungal activities of irrigation well water-bacteria

Tabli N, Rai A, Bensidhoum L, Palmieri G, Gogliettino M, Cocca E, Consiglio C, Cillo F, Bubici G, Nabti E

Year: 2017

Adaptive response activated by dietary cis9, trans11 conjugated linoleic acid prevents distinct signs of gliadin-induced enteropathy in mice

Bergamo P, Palmieri G, Cocca E, Ferrandino I, Gogliettino M, Monaco A, Maurano F, Rossi M

Year: 2016

Uncommon functional properties of the first piscine 26S proteasome from the Antarctic notothenioid Trematomus bernacchii

Gogliettino M, Balestrieri M, Riccio A, Facchiano A, Fusco C, Palazzo VC, Rossi M, Cocca E, Palmieri G

Year: 2016

APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome

Palumbo R, Gogliettino M, Cocca E, Iannitti R, Sandomenico A, Ruvo M, Balestrieri M, Rossi M, Palmieri G

Year: 2016

A New APEH Cluster with Antioxidant Functions in the Antarctic Hemoglobinless Icefish Chionodraco hamatus

Riccio A, Gogliettino M, Palmieri G, Balestrieri M, Facchiano A, Rossi M, Palumbo S, Monti G, Cocca E

Year: 2015

A novel class of bifunctional acylpeptide hydrolases

Gogliettino M, Riccio A, Balestrieri M, Cocca E, Facchiano A, D’arco Tm, Tesoro C, Rossi M, Palmieri G

Year: 2014

A new pepstatin-insensitive thermopsin-like protease overproduced in peptide-rich cultures of sulfolobus solfataricus

Gogliettino M, Riccio A, Cocca E, Rossi M, Palmieri G, Balestrieri M

Year: 2014

RedOx Status, Proteasome and APEH: Insights into Anticancer Mechanisms of t10,c12-Conjugated Linoleic Acid Isomer on A375 Melanoma Cells

Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G

Year: 2013

Structural and Functional Insights into Aeropyrum pernix OppA, a Member of a Novel Archaeal OppA Subfamily

Balestrieri M, Gogliettino M, Fiume I, Pocsfalvi G, Catara G, Rossi M, Palmieri G

Year: 2011

Conjugated linoleic acid protects against gliadin-induced depletion of intestinal defenses

Bergamo P, Gogliettino M, Palmieri G, Cocca E, Maurano F, Stefanile R, Balestrieri M, Mazzarella G, David C, Rossi M

Year: 2011