Stefania Crispi

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Education and Training:

1987: Degree in Biological Sciences (110/110), University of Naples "Federico II"

1988: Post - laurea training at Dept of Genetics, General and Molecular Biology, University of Naples "Federico II"

1989-1994: PhD in Cellular and Molecular Genetics

1995-1997: Post- doctoral fellowship at University of Naples "Federico II"

2005: Second level Master degree in Phytotherapy - University of Siena

Research Experiences:

2013-present: group leader at the Institute of Biosciences and BioResources UOS of Naples - CNR, Gene Expression and Molecular Genetics Laboratory.

2008-2013: staff scientist at the Institute of Genetics and Biophysics, "Adriano Buzzati Traverso"-CNR. Scientific coordinator of the Expression profiling lab.

2005-2007: guest researcher at the Institute of Genetics and Biophysics, "Adriano Buzzati Traverso"- CNR. Supervisor of the Gene Expression Core Human Molecular Genetics.

2001-2004: BioGeM researcher, at the Institute of Genetics and Biophysics "Adriano Buzzati Traverso"-CNR, Naples. Project “I geni nell’uomo”.

1998-2000: CEINGE researcher, project P.S.T. “Biotecnologie Mediche ed Agroalimentari”.

Selected Publications

Piccolo MT, Menale C, Crispi S. Combined anticancer therapies: an overview of the latest applications. ACAMC 2015, In press

Menale C, Piccolo MT, Favicchia I, Aruta MG, Baldi A, Nicolucci C, Barba V, Mita DG, Crispi S, Diano N. Efficacy of Piroxicam Plus Cisplatin-Loaded PLGA Nanoparticles in Inducing Apoptosis in Mesothelioma Cells. Pharm Res 2014 Aug 5.

Colasante G, Simonet JC, Calogero R, Crispi S, Sessa A, Cho G, Golden JA, Broccoli V. ARX Regulates Cortical Intermediate Progenitor Cell Expansion and Upper Layer Neuron Formation Through Repression of Cdkn1c. Cereb Cortex. 2013 Aug 22.

Crispi S, Piccolo MT, D’Avino A, Donizetti A, Viceconte R, Spyrou M, Calogero RA, Baldi A, Signorile PG. Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects. J Cell Physiol. 2013, 228(9):1927-34.

Baldi A, Piccolo MT, Boccellino MR, Donizetti A, Cardillo I, La Porta R, Quagliuolo L, Spugnini EP, Cordero F, Citro G, Menegozzo M, Calogero RA, Crispi S. Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.

Costa V, Angelini C, D’Apice L, Mutarelli M, Casamassimi A, Sommese L, Gallo MA, Aprile M, Esposito R, Leone L, Donizetti A, Crispi S, Rienzo M, Sarubbi B, Calabrò R, Picardi M, Salvatore P, Infante T, De Berardinis P, Napoli C, Ciccodicola A. Massive-scale RNA-Seq analysis of non ribosomal transcriptome in human trisomy 21. PLoS One. 2011 Apr 20;6(4):e18493.

Tosti N, Pasqualini S, Borgogni A, Ederli L, Falistocco E, Crispi S, Paolocci F. Gene expression profiles of O3-treated Arabidopsis plants. Plant Cell Environ. 2006 Sep;29(9):1686-702.

Quaglino E, Rolla S, Iezzi M, Spadaro M, Musiani P, De Giovanni C, Lollini PL, Lanzardo S, Forni G, Sanges R, Crispi S, De Luca P, Calogero R, Cavallo F. Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions. J Clin Invest. 2004 Mar;113(5):709-17.

Present Collaborations

Raffaele Calogero, Bioinformatics and Genomics Unit- MBC, University of Turin.

Gustavo Mita, Institute of Biostructures and Biosystems, Rome

Alfonso Baldi, Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples.

Nadia Diano, Department of Experimental Medicine, Second University of Naples.

Laura Mayol, Department of Pharmacy University of Naples “Federico II”.

Marco Biondi, Department of Pharmacy University of Naples “Federico II”.

Vania Broccoli, DIBIT- San Raffaele Scientific Institute - Milano.

Selected Publications

(full list available at CNR People)

The Antioxidant Effect of Dietary Bioactives Arises from the Interplay between the Physiology of the Host and the Gut Microbiota: Involvement of Short-Chain Fatty Acids

Cuciniello R, Di Meo F, Filosa S, Crispi S, Bergamo P

Year: 2023

Ginkgo biloba prevents oxidative stress-induced apoptosis blocking p53 activation in neuroblastoma cells

Di Meo F, Cuciniello R, Margarucci S, Bergamo P, Petillo O, Peluso G, Filosa S, Crispi S

Year: 2020

New therapeutic drugs from bioactive natural molecules: the role of gut microbiota metabolism in neurodegenerative diseases

Di Meo F, Donato S, Di Pardo A, Maglione V, Filosa S, Crispi S

Year: 2018

I17 Curcumin-supplemented diet preserves body weight and ameliorates intestinal functionality in R6/2 mice

Elifani F, Castaldo S, Capocci L, Rosa P, Montano E, Calogero A, Filosa S, Crispi S, Maglione V, Di Pardo A

Year: 2018

Polyphenols-gut microbiota interplay and brain neuromodulation

Filosa S, Di Meo F, Crispi S

Year: 2018

Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease

Di Pardo A, Amico E, Scalabrì F, Pepe G, Castaldo S, Elifani F, Capocci L, De Sanctis C, Comerci L, Pompeo F, D’esposito M, Filosa S, Crispi S, Maglione V

Year: 2017

Olive compounds attenuate oxidative damage induced in HEK-293 cells via MAPK signaling pathway

Maalej A, Forte M, Bouallagui Z, Donato S, Mita L, Mita DG, Filosa S, Crispi S, Sayadi S

Year: 2017

Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children

Menale C, Grandone A, Nicolucci C, Cirillo G, Crispi S, Di Sessa A, Marzuillo P, Rossi S, Mita DG, Perrone L, Diano N, Miraglia Del Giudice E

Year: 2017

Nano-precipitated curcumin loaded particles: effect of carrier size and drug complexation with (2-hydroxypropyl)-β-cyclodextrin on their biological performances

Serri C, Argirò M, Piras L, Mita DG, Saija A, Mita L, Forte M, Giarra S, Biondi M, Crispi S, Mayol L

Year: 2017

Triclosan and bisphenol a affect decidualization of human endometrial stromal cells

Forte M, Mita L, Cobellis L, Merafina V, Specchio R, Rossi S, Mita DG, Mosca L, Castaldi MA, De Falco M, Laforgia V, Crispi S

Year: 2016

Ran signaling in melanoma: Implications for the development of alternative therapeutic strategies

Caputo E, Wang E, Valentino A, Crispi S, De Giorgi V, Fico A, Ficili B, Capone M, Anniciello A, Cavalcanti E, Botti G, Mozzillo N, Ascierto PA, Marincola FM, Travali S

Year: 2015

Curcumin loaded PLGA-poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells.

Mayol L, Serri C, Menale C, Crispi S, Piccolo MT, Mita L, Giarra S, Forte M, Saija A, Biondi M, Mita DG

Year: 2015

Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders

Menale C, Piccolo MT, Cirillo G, Calogero RA, Papparella A, Mita L, Del Giudice EM, Diano N, Crispi S, Mita DG

Year: 2015

Combined Anticancer Therapies: an Overview of the Latest Applications

Piccolo MT, Menale C, Crispi S

Year: 2015

Efficacy of Piroxicam Plus Cisplatin-Loaded PLGA Nanoparticles in Inducing Apoptosis in Mesothelioma Cells

Menale C, Piccolo MT, Favicchia I, Aruta MG, Baldi A, Nicolucci C, Barba V, Mita DG, Crispi S, Diano N

Year: 2014